ArticleNigerian medical journal : journal of the Nigeria Medical Association
The immunological and virological correlates of Cervical Precancerous Lesions among HIV-Infected Women on ART in Faith Alive Hospital, Jos, Nigeria.
Article in Nigerian medical journal : journal of the Nigeria Medical Association. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Immuno-suppression in women living with HIV (WLHIV) increases the persistence of high-risk human papillomavirus (HPV) and reduces the ability to clear cervical precancerous lesions; as such, WLHIV are more predisposed to cervical cancer. Widespread use of antiretroviral therapy (ART) among WLHIV enhances immune reconstitution, controlling HIV replication and reversing the weakened immune system. This impedes HPV persistence and the development of precancerous lesions. The immune status of WLHIV is related to their CD4 count and viral load. These factors are impacted by the duration of effective ART. This study aimedto determine the association between cervical precancerous lesions with viral load, CD4 count, and duration on ART among WLHIV. Methodology: A retrospective study on 1113 WLHIV aged 16 -55 years screened for cervical cancer using visual inspection with acetic acid (VIA) and visual inspection with Lugol's iodine (VILI) within a 16-month period in Faith Alive Hospital, Jos, Nigeria. Sociodemographic characteristics of study participants, CD4 count, viral load, duration on ART, and screening results were documented. The data were analysed using IBM-SPSS 26, and logistic regression was performed to determine factors associated with pre-cancerous lesions. Results: The prevalence of cervical precancerous lesions was 9.1%, the prevalence of suspected cancer was 1.6% and the mean age of clients with pre-cancerous lesions was 41.32±9.89 years. Unsuppressed baseline viral load (≥1000 copies/ml) and <6 months of exposure to ART were found to be strongly associated with cervical precancerous lesions. Conclusion: This study demonstrated a higher burden of cervical precancerous lesions in viral unsuppressed women on ART initiation and in women with <6 months of exposure to antiretroviral therapy. Early commencement and prolonged use of ART on WLHIV to ensure early and sustained viral suppression to reduce the risk of cervical cancer is recommended.
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