ArticlePsychological medicine2025
Three-year outcome comparison between extended early intervention and standard psychiatric care for adults with first-episode psychosis in Hong Kong.
Article in Psychological medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Abstract
backgroundEarly intervention (EI) for first-episode psychosis (FEP) mainly focuses on adolescents and young adults. Previous evaluation demonstrated superiority of 2-year EI program (EASY) over standard care in outcome improvement in young people (15-25 years) with FEP in Hong-Kong. However, effectiveness of territory-wide extended EASY, which provides 3-year EI service also to adult patients aged ≥26 years, has not been systematically examined.
methodsThis study adopted historical control-case design, comparing patients aged 26-55 years who had received extended EI (EI-group,
resultsOur results showed that EI-group had significantly shorter DUP than SC-group. Additionally, EI-group displayed fewer average positive symptoms in the first and second year of follow-up, lower levels of negative and depressive symptoms, better global and social functioning, and higher quality of life on physical domain than SC-group at 3 years of follow-up. Our findings indicate that adult FEP patients receiving 3-year extended EI service had better clinical and functional outcomes than those managed by standard psychiatric care.
conclusionsOur results thus provide real-world evidence supporting the superiority and implementation of 3-year extended EASY program for adult FEP patients in shortening of treatment delay and improvement of symptom and functional outcomes.
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