ArticleInternational journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics2026
Comparative evaluation of prophylactic strategies for postpartum hemorrhage in vaginal delivery.
Article in International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Prevalence, emerging aetiologies, and contemporary predictors of primary postpartum haemorrhage in a tertiary-level obstetric population in Nnewi, Nigeria: a pilot study.Kronika (Ljubljana, Slovenia) · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo compare the efficacy of different prophylactic oxytocin regimens in preventing postpartum hemorrhage (PPH) after vaginal delivery.
methodsSingle-center retrospective cohort study including all vaginal deliveries between February 1, 2022, and December 31, 2023, at a tertiary referral unit. Throughout the study period, the local protocol for PPH prevention in vaginal delivery was changed from oxytocin 10 IU intramuscular injection (IM) to 5 IU intravenous bolus (IV) and eventually to 10 IU IV. Data regarding base maternal characteristics, pregnancy course, labor, and maternal outcomes were retrospectively collected from institutional labor ward registries. The incidence of PPH was compared among the three historical cohorts who received different oxytocin regimens (10 IU IM, group A; 5 IU IV, group B; and 10 IU IV, group C) following propensity score matching for those variables that proved to be significantly associated with PPH.
resultsDuring the study period, 3850 women had a vaginal birth at our tertiary care unit (1245 in the 10 IU IM group, 1291 in the 5 IU IV group and 1314 in the 10 IU IV group) and were enrolled in the study population. Of these, 688 (17.8%) had PPH. At multivariable logistic regression nulliparity, second-degree or higher perineal tears, episiotomy, manual placental removal, birth weight, and multiple gestation appeared to be independently associated with PPH. PPH incidence was then compared among the groups following 1:1 propensity score matching for the above cited factors and appeared significantly higher with the use of 10 IU IM (group A) versus 5 IU IV (group B) oxytocin (21.3% versus 11.0%; P < 0.001) and versus 10 IU IV (group C) (22.1% versus 16.8%; P = 0.033); non-significant differences between the incidence of PPH were observed when comparing the two regimens of IV administration.
conclusionIntravenous administration of 5 IU or 10 IU is more effective than IM administration of 10 IU in reducing the incidence of PPH after vaginal deliveries. The efficacy of the two IV regimens appears similar.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.