Evidence map›Paper›PMID 41189325›Full record

ArticleBiophysical journal2026

Interplay between Rac1/RhoA and actin waves in giant epithelial cells: Experiment and theory.

Rémi Berthoz, He Li, Marie André, Michèle Lieb, Lucien Hinderling, Benjamin Grädel, Jakobus Van Unen, Olivier Pertz, Karsten Kruse, Daniel Riveline

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PubMed Full text at PMC Publisher
In one paragraph

Article in Biophysical journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Rémi BerthozInstitut de Génétique et de Biologie Moléculaire et Cellulaire, Illkirch, France; Université de Strasbourg, Illkirch, France; Centre National de la Recherche Scientifique, UMR7104, Illkirch, France; Institut National de la Santé et de la Recherche Médicale, U964, Illkirch, France.
He LiInstitut de Génétique et de Biologie Moléculaire et Cellulaire, Illkirch, France; Université de Strasbourg, Illkirch, France; Centre National de la Recherche Scientifique, UMR7104, Illkirch, France; Institut National de la Santé et de la Recherche Médicale, U964, Illkirch, France.
Marie AndréInstitut de Génétique et de Biologie Moléculaire et Cellulaire, Illkirch, France; Université de Strasbourg, Illkirch, France; Centre National de la Recherche Scientifique, UMR7104, Illkirch, France; Institut National de la Santé et de la Recherche Médicale, U964, Illkirch, France.
Michèle LiebInstitut de Génétique et de Biologie Moléculaire et Cellulaire, Illkirch, France; Université de Strasbourg, Illkirch, France; Centre National de la Recherche Scientifique, UMR7104, Illkirch, France; Institut National de la Santé et de la Recherche Médicale, U964, Illkirch, France.
Lucien HinderlingInstitute of Cell Biology, University of Bern, Baltzerstrasse 4, 3012 Bern, Switzerland.
Benjamin GrädelInstitute of Cell Biology, University of Bern, Baltzerstrasse 4, 3012 Bern, Switzerland.
Jakobus Van UnenInstitute of Cell Biology, University of Bern, Baltzerstrasse 4, 3012 Bern, Switzerland.
Olivier PertzInstitute of Cell Biology, University of Bern, Baltzerstrasse 4, 3012 Bern, Switzerland.
Karsten KruseDepartment of Biochemistry, University of Geneva, 1211 Geneva, Switzerland; Department of Theoretical Physics, University of Geneva, 1211 Geneva, Switzerland. Electronic address: karsten.kruse@unige.ch.
Daniel RivelineInstitut de Génétique et de Biologie Moléculaire et Cellulaire, Illkirch, France; Université de Strasbourg, Illkirch, France; Centre National de la Recherche Scientifique, UMR7104, Illkirch, France; Institut National de la Santé et de la Recherche Médicale, U964, Illkirch, France. Electronic address: riveline@unistra.fr.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The acto-myosin cytoskeleton is a key driver of cellular shape changes in vivo and in vitro. Acto-myosin organization results from actin assembly and interactions between actin and myosin, which are both regulated by small Rho GTPases like Rac1 and RhoA. To uncover principles governing cytoskeletal organization, we analyzed actin patterns using live microscopy and theory in flat cortical layers of enlarged cells. This allowed us to characterize their evolution within an extended continuous cortical surface and distant from lateral cell boundaries or cell-cell junctions. In giant Madin-Darby Canine Kidney epithelial cells, we observed acto-myosin stress fibers and propagating waves, which were similar to structures we observed also in REF52 fibroblasts. Stress fibers were stationary and correlated with homogeneous distributions of Rac and RhoA activity. Waves propagated at ≈1μmmin

Indexed as

ActinsEpithelial CellsModels, Biologicalrac1 GTP-Binding ProteinrhoA GTP-Binding ProteinAnimalsDogsMadin Darby Canine Kidney CellsMyosinsStress FibersActinsMyosinsrac1 GTP-Binding ProteinrhoA GTP-Binding Protein

Identifiers

PMID41189325
PMCPMC13507471

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.