ArticleJournal of cutaneous medicine and surgery
Concurrent Hidradenitis Suppurativa and Pyoderma Gangrenosum in a Pediatric Cohort: A Retrospective Case Series.
Article in Journal of cutaneous medicine and surgery. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundHidradenitis suppurativa (HS) and pyoderma gangrenosum (PG) are chronic neutrophilic dermatoses characterized by dysregulated inflammation. Their coexistence in adults has been reported, but this has not been well documented in pediatric populations.
objectivesTo characterize the overlap, clinical characteristics, and treatment options for pediatric patients with concurrent HS and PG.
methodsWe conducted a retrospective case series of pediatric patients ages 3 to 17 with clinical diagnoses of HS and PG at The Hospital for Sick Children between January 2015 and January 2022. Demographic, clinical, laboratory, genetic, and treatment data were extracted from electronic medical records and analyzed descriptively.
resultsSeven of 122 pediatric HS patients (5.7%) had concurrent PG. HS onset preceded PG in all cases, with mean onset ages of 11.6 and 16.1 years, respectively. The cohort had a slight male predominance (57%) and high rates of comorbidities, including obesity (71.4%) and acne conglobata (42.9%). Elevated erythrocyte sedimentation rate (ESR) (mean 56.9 mm/hour) was a significant predictor of HS severity (
conclusionsPediatric patients with HS-PG may represent a distinct, severe inflammatory subset. Further investigation is needed to define risk factors, inflammatory biomarkers, and optimal treatment strategies in this rare overlap population.
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