Evidence map›Paper›PMID 41189097›Full record

ArticleAnimal models and experimental medicine2025

Bilateral carotid-jugular arteriovenous graft implantation in an ovine model is safe and durable for facilitation of arteriovenous graft innovation.

Matthew Schneck, Gregory Brittenham, Yi Cheng, Taylor Tran, Matthew Vuoncino, Christopher Pivetti, Aijun Wang, Mimmie Kwong

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Animal models and experimental medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Matthew SchneckDepartment of Surgery, University of California Davis, Sacramento, California, USA.ORCID 0000-0002-3434-4552
Gregory BrittenhamDepartment of Surgery, University of California Davis, Sacramento, California, USA.
Yi ChengDepartment of Surgery, University of California Davis, Sacramento, California, USA.
Taylor TranDepartment of Surgery, University of California Davis, Sacramento, California, USA.
Matthew VuoncinoDepartment of Surgery, University of California Davis, Sacramento, California, USA.
Christopher PivettiDepartment of Surgery, University of California Davis, Sacramento, California, USA.
Aijun WangDepartment of Surgery, University of California Davis, Sacramento, California, USA.
Mimmie KwongDepartment of Surgery, University of California Davis, Sacramento, California, USA.

Funding

California Institute for Regenerative Medicine (CIRM) TRAN3-13332
6 · The paper itself

Abstract

Over 550 000 people in the U.S. require hemodialysis for management of end stage renal disease (ESRD). When anatomy restricts fistula creation, arteriovenous grafts (AVG) are implanted. AVGs have poor primary patency and high risk of infection, highlighting a need for better alternatives. Previous AVG large animal models were limited by high complication rates and short-term follow-up. This study investigates the safety and durability of an ovine bilateral carotid-jugular AVG model. Eight female sheep underwent bilateral carotid-jugular AVG implantation via a single longitudinal incision overlying the trachea. Ringed PTFE grafts were anastomosed in a "lazy-S" configuration to provide the laxity needed to prevent avulsion and minimize kinking with neck movement. Post-operatively, sheep were evaluated daily to monitor for complications. Duplex ultrasonography of the grafts was performed at regular intervals out to 6 months to evaluate patency. At 6 months, angiography and duplex was performed followed by explant for gross and histologic analysis. Technical success was achieved in 16 of 16 (100%) graft implants. No major complications, including stroke, anastomotic disruption, infection, wound breakdown, or death occurred. Primary patency of control PTFE grafts was 75% at 6 months, paralleling reported rates in humans. Bilateral carotid-jugular AVG implantation in sheep is a safe and durable model for self-controlled long-term evaluation of AVG conduit technology.

Indexed as

Arteriovenous Shunt, SurgicalBlood Vessel Prosthesis ImplantationCarotid ArteriesJugular VeinsAnimalsBlood Vessel ProsthesisFemaleModels, AnimalPolytetrafluoroethyleneRenal DialysisSheepVascular PatencyPolytetrafluoroethyleneAnimalBiomedicalModelsPolytetrafluoroethyleneRenal DialysisSheepTranslational ResearchVascular Patency

Identifiers

PMID41189097
PMCPMC12660499

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.