ArticleBreast cancer research : BCR2025
Neighborhood deprivation, breast cancer outcomes and stress-related gene expression in leukocytes and tumor tissue.
Article in Breast cancer research : BCR, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Social genomics and cancer - untangling nature from nurture in squamous cell carcinoma outcomes.Frontiers in oncology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
backgroundNeighborhood socioeconomic deprivation is a recognized contributor to disparities in breast cancer outcomes, yet the biological mechanisms linking neighborhood context to tumor behavior remain poorly defined. The conserved transcriptional response to adversity (CTRA), characterized by upregulation of pro-inflammatory genes and downregulation of type I interferon and antibody-related genes, may represent a stress-related immune dysregulation pathway relevant to cancer aggressiveness and survival.
methodsWe examined associations among the Area Deprivation Index (ADI), CTRA gene expression profiles, tumor characteristics, and survival outcomes across two cohorts. Cohort 1 included 467 breast cancer patients treated at M.D. Anderson Cancer Center, with RNA-seq data from peripheral leukocytes used to evaluate associations of ADI with CTRA and tumor characteristics at baseline. Cohort 2 comprised 1082 TCGA breast cancer patients with RNA-seq data from tumor tissue analyzed to assess the prognostic relevance of CTRA. CTRA scores were calculated using established gene signatures. Multivariable regression and Cox proportional hazards models were applied.
resultsIn Cohort 1, higher ADI was significantly associated with elevated CTRA and pro-inflammatory gene expression in leukocytes (ρ = 0.082, p = 0.01). These immune profiles correlated with ER-negative status, stage III disease, and poor tumor differentiation. In TCGA (Cohort 2), elevated tumor CTRA expression was independently associated with worse overall survival (HR = 1.36, 95% CI: 1.04, 1.78, p = 0.02).
conclusionsThese findings suggest that neighborhood socioeconomic disadvantage may influence systemic immune regulation through stress-related transcriptional responses, which in turn contribute to tumor aggressiveness and survival disparities in breast cancer.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.