ArticleGenome medicine2025
Single-cell multi-omics analysis revealed the expansion of age-associated B cells in the pancreas of type 1 autoimmune pancreatitis patients.
Article in Genome medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Single-cell RNA sequencing and high-dimensional flow cytometry reveal distinct peripheral immune landscapes of type 1 autoimmune pancreatitis and pancreatic ductal adenocarcinoma.Clinical and translational medicine · 2026Article
- The pathogenic role of double-negative B cells in autoimmune diseases.Frontiers in immunology · 2026Review
- Single-cell multi-omics analysis revealed the expansion of age-associated B cells in the pancreas of type 1 autoimmune pancreatitis patients.Genome medicine · 2025Article
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21 authors.
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Abstract
backgroundType 1 autoimmune pancreatitis (AIP) is pancreatic manifestation of IgG4-related disease (IgG4-RD), characterized by pancreatic lymphoplasmacytic infiltration. Despite this well-known pathological feature, the immune microenvironment and the complex cellular interactions within the pancreas in AIP remain poorly understood. This study aimed to characterize the local immune features of the pancreas in AIP patients.
methodsWe employed single-cell RNA sequencing (scRNA-seq), immune receptor repertoire sequencing (scTCR/BCR-seq), and spatial transcriptome sequencing on biopsy samples from lesion tissues of AIP patients. Flow cytometry, multicolour immunofluorescence, and functional assays were performed to validate the findings from bioinformatics analysis.
resultsOur results revealed an increased presence of IgD
conclusionsThese findings highlight significant alterations in the pancreatic immune microenvironment in AIP and propose a potential pathogenic model involving ABCs, Tfhs, and macrophages. This model provides valuable insights that could inform the development of targeted therapeutic strategies for AIP.
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