ArticleBMC pulmonary medicine2025
Safety and efficacy of bronchoscopic interventions for tracheobronchial mucormycosis: a 27-patient retrospective cohort study.
Article in BMC pulmonary medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Pulmonary mucormycosis with endobronchial involvement due toMedical mycology case reports · 2026Article
- Invasive tracheal mucormycosis causing irreversible glottic closure and long-term tracheostomy dependence: a case report and airway-centered management implications.Frontiers in medicine · 2026Article
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Authors and funding
8 authors.
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Abstract
backgroundTracheobronchial mucormycosis (TM) is characterized by tracheobronchial obstruction and stenosis. This study describes our clinical experience with bronchoscopic interventions for managing TM.
methodsA retrospective analysis of TM patients was conducted at the Affiliated Hospital of Yunnan University, with a focus on clinical manifestations and treatment information.
resultsA total of 27 patients with TM were included. CT imaging revealed tracheobronchial stenosis (51.9%) and obstructive lesions (33.3%). Bronchoscopy showed mucosal necrosis (92.6%) and lumen obstruction (22.2%). All patients received at least one endoscopic intervention or bronchoscopic AmBD instillation. Bronchoscopic AmBD instillation was administered to 26 patients (96.3%), averaging 5.7 sessions per patient. Bronchoscopic intervention was performed in 19 patients (70.4%), averaging 4.1 sessions per patient. Common techniques included argon plasma coagulation (12 patients, 33 procedures), electrocautery (13 patients, 21 procedures) and cryotherapy (8 patients, 19 procedures). Mild bleeding occurred in 29.6% of cases during interventions. Follow-up data showed complete remission in 16 patients (59.3%), improvement in 4 (14.8%), and death in 7 (25.9%).
conclusionTo date, this constitutes the largest reported case series of TM. Notably, bronchoscopic treatment, comprising AmBD instillation and interventional therapy, serves as a safe and effective approach in the comprehensive management of TM.
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