ArticleBMC medicine2025
Impaired emotional processing in insomnia: REM sleep beta power and frontal cortex activation.
Article in BMC medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Aerobic Exercise and Subthreshold Depressive Symptoms in Adolescents: Secondary Analysis of a Randomized Clinical Trial.JAMA network open · 2026Trial
- Insomnia as a Public Health Issue: Sociomedical Determinants in the Adult Population of Serbia.Medicina (Kaunas, Lithuania) · 2026Article
- Sleep Disruption and Shift Work Associate with Increased Risk of Reproductive Endocrine Disorders: Evidence from UK Biobank and Mendelian Randomization.International journal of women's health · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
backgroundInsomnia disorder is frequently associated with emotional dysregulation, but the underlying neural basis of emotion processing and its relationship to hyperarousal biomarkers, such as beta power during rapid eye movement (REM) sleep, remain unclear. In this study, we investigated the neural basis of emotional processing in patients with insomnia disorder (ID) and explored its association with electroencephalography (EEG) measures, focusing on REM sleep beta power.
methodsThirty-five ID and 34 age- and gender-matched healthy controls (HC) completed questionnaires, underwent whole-night portable single-channel EEG at home, and performed an emotion-matching task under functional Magnetic Resonance Imaging (fMRI). Between-group comparisons were conducted on behavioral measures and brain activations. Partial correlations were used to examine the relationships between significantly activated brain regions during the emotion-matching task and REM sleep beta power recorded overnight.
resultsBehavioral results showed that, regardless of emotional valence, ID had significantly longer mean reaction times than HC. Whole-brain analysis of variance of task fMRI revealed that, in response to happy faces, ID exhibited significantly greater activation in the right superior temporal gyrus, medial orbital frontal cortex (mOFC), superior occipital gyrus, precentral gyrus, and left paracentral lobule compared to HC. Furthermore, after controlling for depression and anxiety symptoms, a significant negative correlation was observed in ID between REM sleep beta power and right mOFC activation in response to happy faces (r = - 0.628, p = 0.005), whereas no such correlation was found in HC.
conclusionsThis study suggests that increased mOFC activation in response to positive emotional stimuli may reflect altered emotion regulation in ID. Sleep-related hyperarousal may be linked to changes in emotion processing, providing preliminary insight into the neural basis of emotional dysregulation in insomnia.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.