ArticleCardiovascular diabetology2025
Elevated triglyceride-glucose index and its combination with anthropometric indices as indicators of the risk of new-onset transient ischemic attack: a prospective cohort study.
Article in Cardiovascular diabetology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Anthropometry-adjusted TyG indices predict diabetes, graft failure, and mortality in kidney transplant recipients.Journal of the Endocrine Society · 2026Article
- Associations of the atherogenic index of plasma and its modified indices with the incidence and progression of cardiometabolic multimorbidity in individuals with cardiovascular-kidney-metabolic syndrome stages 0-3: a prospective cohort study.Cardiovascular diabetology · 2026Article
- Associations of nine insulin resistance-related indices with the incidence and progression of cardiovascular-liver-metabolic multimorbidity: a large prospective cohort study.Cardiovascular diabetology · 2026Article
- The associations of the triglyceride-glucose index and estimated glucose disposal rate with incident cardiometabolic multimorbidity vary across obesity phenotypes: a longitudinal cohort study.Frontiers in nutrition · 2026Article
- Platelet to high-density lipoprotein cholesterol ratio predicts clinical outcomes after acute ischemic stroke: a prospective cohort study.Frontiers in neurologyArticle
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Abstract
backgroundThe association between the triglyceride-glucose (TyG) and combined anthropometric indices with transient ischemic attack (TIA) has not previously been explored in detail. This study investigated the relationship of TyG and anthropometric indices with incident TIA in healthy populations.
methodsData from a prospective UK Biobank cohort (361,336 participants) were analyzed using Cox regression, population attributable fraction (PAF), restricted cubic splines (RCS), and receiver operating characteristic (ROC) curves. Robustness was evaluated using subgroup and interaction analyses and sensitivity tests.
resultsDuring a median follow-up of 13.7 years, TyG, glucose triglyceride-waist circumference (TyG-WC), glucose triglyceride-body mass index (TyG-BMI), glucose triglyceride-waist height ratio (TyG-WHtR), visceral adiposity index (VAI), and lipid accumulation product (LAP) were significantly associated with increased TIA risk (all P < 0.001). Cox regression analysis revealed that participants in the highest quartile (Q4) had higher hazard ratios (HRs) than those in the lowest quartile (Q1): TyG (HR: 1.22, 95% confidence interval [CI]: 1.12-1.33); TyG-WC (HR: 1.29, 95% CI: 1.17-1.42); TyG-BMI (HR: 1.21, 95% CI: 1.11-1.33); TyG-WHtR (HR: 1.29, 95% CI: 1.18-1.42); VAI (HR: 1.35, 95% CI: 1.24-1.47); and LAP (HR: 1.29, 95% CI: 1.18-1.42). PAF analysis indicated that maintaining Q1 levels of indices for TyG, TyG-WC, TyG-BMI, TyG-WHtR, VAI, and LAP could reduce TIA incidence by 9.07%, 14.56%, 11.48%, 15.75%, 17.18%, and 15.83%, respectively. RCS analysis revealed that TIA risk had linear associations with TyG, TyG-WC, and TyG-BMI, and nonlinear associations with TyG-WHtR, VAI, and LAP (P for nonlinear < 0.05). ROC analysis revealed that the indicators with the highest diagnostic accuracy were TyG-WHtR (area under the curve [AUC] 0.678, 95% CI: 0.676-0.679) and TyG-WC (AUC: 0.673, 95% CI: 0.672-0.675). Subgroup analysis identified age (P < 0.001) and diabetes (P = 0.021) as significant effect modifiers.
conclusionsElevated levels of TyG and combined anthropometric indices are associated with an increased risk of incident TIA. TyG-WHtR and TyG-WC showed a higher accuracy than the TyG index alone as indicators of TIA risk. This study demonstrates the importance of maintaining optimal TyG and anthropometric-related index levels for TIA prevention.
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