Trial reportBMC oral health2025
Comparative evaluation of the effect of different cleaning agents on colour and surface roughness of Invisalign clear aligners: a cross-over randomized controlled trial.
Trial report in BMC oral health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05213650 (Comparative Evaluation of Cleaning Agents on Color and Roughness of Invisalign Clear Aligners), which is not on this map. Cited by 4 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Comparative Evaluation of Cleaning Agents on Color and Roughness of Invisalign Clear Aligners: A Cross-Over Randomized Trial
Who cites it
4 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Ageing effects on chemical, physical, mechanical, and morphological properties of clear aligners - a systematic review.Progress in orthodontics · 2026Pooled it
- Effect of Staining and Cleaning Agents on the Colour Stability and Surface Roughness of Clear Aligners.Orthodontics & craniofacial research · 2026Article
- Effectiveness of cleaning methods for clear aligners stained with pediatric iron and multivitamin syrups.Scientific reports · 2026Article
- Effects of cleaning methods on the removal efficacy of Streptococcus mutans biofilm and material properties of thermoplastic aligner materials.BMC oral health · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
backgroundRecent advancements in orthodontics have led to the widespread use of clear aligners, appreciated for their aesthetic and comfort advantages. However, standardized cleaning instructions remain undefined, and maintaining the surface integrity of aligners is critical for treatment efficacy and patient satisfaction. Although several studies have evaluated the effects of cleaning agents, comprehensive clinical evidence regarding their impact on the colour stability and surface roughness of Invisalign aligners is still lacking. This study aims to address this gap by comparing the effects of five commonly used cleaning agents on these key properties.
objectivesTo assess the influence of various cleaning agents on both the colour and surface roughness of clear aligners. MATERIALS AND
methodsThis randomized crossover clinical trial included 23 participants with good oral hygiene, each requiring more than 12 aligners. Participants were randomly assigned to use two different cleaning agents in two consecutive treatment phases. The agents tested were: (1) Invisalign Cleaning Crystals (Align Technology, USA), (2) Efferdent Anti-Bacterial Denture Cleanser (Prestige Brands, USA), (3) Sensodyne Rapid Relief toothpaste (GlaxoSmithKline, UK), (4) Signal White Now Whitening Toothpaste (Unilever, USA), and (5) colourant-free clear soap (La Petit Marseillaise, France). Colour measurements (ΔE) were obtained using a spectrophotometer based on the CIE Lab* system, and surface roughness was evaluated with an optical profilometer. Bonferroni-corrected post hoc pairwise comparisons were conducted using Jamovi version 2.6.26.
resultsColourant-free clear soap caused the least colour change, while the Cleaning Crystals and Whitening Toothpaste showed the highest. Control (unused) aligners had greater surface roughness than cleaned aligners. Among cleaning agents, the Cleaning Crystals group exhibited significantly higher roughness than most others (p < 0.05).
conclusionsCleaning agents influence the aesthetic and physical properties of aligners to varying degrees. Colourant-free clear soap demonstrated minimal impact on both colour and surface integrity and may be recommended as a safe and inexpensive option for daily aligner care.
trial registrationClinicalTrials.gov Identifier: NCT05213650. Registered 17 January 2022. Retrospectively registered. This randomized controlled trial adheres to the CONSORT 2010 guidelines for reporting.
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