ArticleBMC plant biology2025
Genome-wide identification and stress response expression analysis of the heavy metal-associated isoprenylated plant protein gene family in tobacco (Nicotiana tabacum L.).
Article in BMC plant biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Genome-wide identification and expression analysis of HMAs gene family in tobacco under abiotic stress.Scientific reports · 2026Article
- Pan-Genome Analysis and Expression Profiling ofGenes · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
backgroundHeavy metal-associated isoprenylated plant proteins (HIPPs) are a class of metallochaperone proteins crucial for plant growth, development, and stress responses. However, a systematic investigation of the tobacco HIPP family has not been conducted.
resultsIn this study, we identified 68 NtHIPP genes, all of which had conserved heavy metal-associated structural domains and the C-terminal isoprenoid motif CaaX. Phylogenetic analyses categorized NtHIPP genes into five clades, with 37 NtHIPP genes unevenly distributed across 18 tobacco chromosomes. Collinearity relationship analysis revealed that segmental duplication was a major factor in the evolution of these genes, and they exhibit a closer evolutionary relationship to dicots (Arabidopsis thaliana and Solanum lycopersicum) compared to monocots (Triticum aestivum and Oryza sativa). RNA-seq data indicated NtHIPP genes had different expression profiles in the shoot apex, shoot, and root, and some genes showing differential expression in response to drought, cold, cadmium stress, and Ralstonia solanacearum infection. Eight NtHIPP genes, as identified via reverse transcription-quantitative Polymerase Chain Reaction (RT-qPCR), exhibited positive or negative responses to various environmental stimuli under abiotic stress and hormone treatments.
conclusionsThis study elucidates the relationship between NtHIPP genes and plant stress responses, providing new candidates for exploring stress-resistant germplasm resources in tobacco.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.