Evidence map›Paper›PMID 41188707›Full record

ArticleBMC genomics2025

Identification and functional characterization of the histone acetyltransferase gene family in Bursaphelenchus xylophilus.

Lichao Wang, Yajing Song, Ruocheng Sheng, Muhammad Faizan Latif, Ming Xu, Yang Wang, Min Li, Fengmao Chen

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PubMed Full text at PMC Publisher
In one paragraph

Article in BMC genomics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Lichao WangCo‑Innovation Center for Sustainable Forestry in Southern China, Nanjing Forestry University, Nanjing, Jiangsu, 210037, China.
Yajing SongCo‑Innovation Center for Sustainable Forestry in Southern China, Nanjing Forestry University, Nanjing, Jiangsu, 210037, China.
Ruocheng ShengCo‑Innovation Center for Sustainable Forestry in Southern China, Nanjing Forestry University, Nanjing, Jiangsu, 210037, China.
Muhammad Faizan LatifCo‑Innovation Center for Sustainable Forestry in Southern China, Nanjing Forestry University, Nanjing, Jiangsu, 210037, China.
Ming XuCo‑Innovation Center for Sustainable Forestry in Southern China, Nanjing Forestry University, Nanjing, Jiangsu, 210037, China.
Yang WangCo‑Innovation Center for Sustainable Forestry in Southern China, Nanjing Forestry University, Nanjing, Jiangsu, 210037, China.
Min LiCo‑Innovation Center for Sustainable Forestry in Southern China, Nanjing Forestry University, Nanjing, Jiangsu, 210037, China.
Fengmao ChenCo‑Innovation Center for Sustainable Forestry in Southern China, Nanjing Forestry University, Nanjing, Jiangsu, 210037, China. cfengmao@njfu.edu.cn.

Funding

Jiangxi Provincial Natural Science Foundation of China 20242BAB25384the National Key Research and Development Program of China 2021YFD1400903
6 · The paper itself

Abstract

backgroundAcetylation is a widely occurring post-translational protein modification in animals, plants, and microorganisms. Histone acetyltransferase (HATs) are positive regulators of acetylation and are responsible for the growth, development, and virulence of pathogens. The pine wood nematode (PWN) Bursaphelenchus xylophilus has caused extensive pine tree mortality, leading to significant loss in Asia; however, there is no HATs have been characterized in PWN.

resultsIn the present study, 7 HATs in PWN were identified and grouped into 3 subfamilies with conserved protein structures and motif compositions. The RT-PCR analysis revealed that HAT expression levels varied across developmental, temperature, and infection stages in pines. After the interference of BxPCAF and BxElp3, two acetyltransferase genes belonging to the GANT subfamily, the reproductive number and the pathogenicity of PWN decreased.

conclusionsWe identified 7 HATs belonging to 3 subfamilies in PWN, and these proteins may play specific roles in undergrowth, environmental stress, and host invasion and are associated with the growth and pathogenicity of PWN.

Indexed as

Helminth ProteinsHistone AcetyltransferasesMultigene FamilyTylenchidaTylenchoideaAnimalsPhylogenyPinusPlant DiseasesHelminth ProteinsHistone AcetyltransferasesBursaphelenchus xylophilusExpression analysisGene functionHistone acetyltransferasesPines

Identifiers

PMID41188707
PMCPMC12584404

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.