Evidence map›Paper›PMID 41188682›Full record

ArticleNutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition2026

Association between serum bicarbonate and low mid-upper arm circumference in patients with non-dialysis-dependent chronic kidney disease: A cross-sectional study.

Nobuhisa Morimoto, Shintaro Mandai, Tamami Fujiki, Fumiaki Ando, Takayasu Mori, Koichiro Susa, Shotaro Naito, Eisei Sohara, Tatsuhiko Anzai, Kunihiko Takahashi and 4 more

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Article in Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

14 authors.

Nobuhisa MorimotoDepartment of Nephrology, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo, Tokyo, Japan.ORCID https://orcid.org/0000-0002-8330-002X
Shintaro MandaiDepartment of Nephrology, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo, Tokyo, Japan.
Tamami FujikiDepartment of Nephrology, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo, Tokyo, Japan.
Fumiaki AndoDepartment of Nephrology, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo, Tokyo, Japan.ORCID https://orcid.org/0000-0002-8401-1705
Takayasu MoriDepartment of Nephrology, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo, Tokyo, Japan.ORCID https://orcid.org/0000-0002-9308-7787
Koichiro SusaDepartment of Nephrology, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo, Tokyo, Japan.
Shotaro NaitoDepartment of Nephrology, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo, Tokyo, Japan.
Eisei SoharaDepartment of Nephrology, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo, Tokyo, Japan.
Tatsuhiko AnzaiDepartment of Biostatistics, M&D Data Science Center, Institute of Integrated Research, Institute of Science Tokyo, Tokyo, Japan.
Kunihiko TakahashiDepartment of Biostatistics, M&D Data Science Center, Institute of Integrated Research, Institute of Science Tokyo, Tokyo, Japan.
Wataru AkitaDepartment of Nephrology, Doai Memorial Hospital, Tokyo, Japan.
Akihito OhtaDepartment of Nephrology, Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital, Tokyo, Japan.
Shinichi UchidaDepartment of Nephrology, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo, Tokyo, Japan.
Soichiro IimoriDepartment of Nephrology, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo, Tokyo, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAlthough previous experimental studies showed that metabolic acidosis promoted muscle catabolism and impaired protein synthesis, few epidemiological studies reported an independent association between serum bicarbonate levels and muscle atrophy in patients with chronic kidney disease (CKD). We examined the association between serum bicarbonate levels and low mid-upper arm circumference (MUAC), a surrogate marker of low muscle mass, in older adults with non-dialysis-dependent CKD.

methodsA total of 174 patients aged ≥65 years with an estimated glomerular filtration rate <60 ml/min/1.73 m

resultsSerum bicarbonate levels were positively associated with MUAC (coefficient = 0.158, 95% CI = 0.026-0.289; P = 0.019). Serum bicarbonate levels <24 mmol/L were associated with a higher prevalence of low MUAC (prevalence ratio = 3.50, 95% CI = 1.61-7.61; P = 0.002), whereas the association was attenuated for serum bicarbonate levels <22 mmol/L. Restricted cubic spline analyses suggested a nonlinear association between serum bicarbonate levels and low MUAC.

conclusionWe found an independent association between serum bicarbonate levels <24 mmol/L and low MUAC, calling for further prospective studies to elucidate the target serum bicarbonate level that would help retard muscle atrophy.

Indexed as

ArmBicarbonatesMuscular AtrophyRenal Insufficiency, ChronicAgedAged, 80 and overCross-Sectional StudiesFemaleGlomerular Filtration RateHumansMaleBicarbonatesarm circumferencechronic kidney diseasemetabolic acidosissarcopeniaserum bicarbonate

Identifiers

PMID41188682
PMCPMC13193409

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.