Evidence map›Paper›PMID 41188611›Full record

ArticlePediatric research2026

Maternal thyroid hormone trajectories and cognitive develpoment in preschoolers: the Ma'anshan Birth Cohort.

Wen Li, Mengjie Zhu, Hong Wei, Manyu Zhang, Shidie Chen, Lu Chen, Juan Tong, Guopeng Gao, Hui Cao, Shuangqin Yan and 2 more

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Article in Pediatric research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Wen LiSchool of Public Health, Key Laboratory of Population Health Across Life Cycle, Ministry of Education of the People's Republic of China, NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract, Anhui Provincial Key Laboratory of Environment and Population Health Across the Life Course, Anhui Medical University, Hefei, Anhui, China.
Mengjie ZhuSchool of Public Health, Key Laboratory of Population Health Across Life Cycle, Ministry of Education of the People's Republic of China, NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract, Anhui Provincial Key Laboratory of Environment and Population Health Across the Life Course, Anhui Medical University, Hefei, Anhui, China.
Hong WeiSchool of Public Health, Key Laboratory of Population Health Across Life Cycle, Ministry of Education of the People's Republic of China, NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract, Anhui Provincial Key Laboratory of Environment and Population Health Across the Life Course, Anhui Medical University, Hefei, Anhui, China.
Manyu ZhangSchool of Public Health, Key Laboratory of Population Health Across Life Cycle, Ministry of Education of the People's Republic of China, NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract, Anhui Provincial Key Laboratory of Environment and Population Health Across the Life Course, Anhui Medical University, Hefei, Anhui, China.
Shidie ChenSchool of Public Health, Key Laboratory of Population Health Across Life Cycle, Ministry of Education of the People's Republic of China, NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract, Anhui Provincial Key Laboratory of Environment and Population Health Across the Life Course, Anhui Medical University, Hefei, Anhui, China.
Lu ChenSchool of Public Health, Key Laboratory of Population Health Across Life Cycle, Ministry of Education of the People's Republic of China, NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract, Anhui Provincial Key Laboratory of Environment and Population Health Across the Life Course, Anhui Medical University, Hefei, Anhui, China.
Juan TongSchool of Public Health, Key Laboratory of Population Health Across Life Cycle, Ministry of Education of the People's Republic of China, NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract, Anhui Provincial Key Laboratory of Environment and Population Health Across the Life Course, Anhui Medical University, Hefei, Anhui, China.
Guopeng GaoMa'anshan Maternal and Child Health Center, Ma'anshan, China.
Hui CaoMa'anshan Maternal and Child Health Center, Ma'anshan, China.
Shuangqin YanMa'anshan Maternal and Child Health Center, Ma'anshan, China.
Fangbiao TaoSchool of Public Health, Key Laboratory of Population Health Across Life Cycle, Ministry of Education of the People's Republic of China, NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract, Anhui Provincial Key Laboratory of Environment and Population Health Across the Life Course, Anhui Medical University, Hefei, Anhui, China.
Kun HuangSchool of Public Health, Key Laboratory of Population Health Across Life Cycle, Ministry of Education of the People's Republic of China, NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract, Anhui Provincial Key Laboratory of Environment and Population Health Across the Life Course, Anhui Medical University, Hefei, Anhui, China. ahmuhuangk@163.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTo examine the potential effect of thyroid hormone trajectories on children's cognitive development (3-6 years) and the critical period when maternal thyroid dysfunction during pregnancy might act.

methodsBased on Ma'anshan Birth Cohort (MABC) in China, pregnant women were recruited at their first antenatal checkup from May 2013 to September 2014. A total of 1843 mother-child pairs were included in the analysis. Maternal thyroid hormones were repeatedly assayed in early, mid and late pregnancy. The dynamic changes of FT

resultsMaternal low FT

conclusionWe found that high T IMPACT: The study was based on a large prospective birth cohort study platform for thyroid hormone trajectory fitting using repeated measurements in the early, mid, and late pregnancy. The low maternal FT

Indexed as

Child DevelopmentCognitionPrenatal Exposure Delayed EffectsThyroid HormonesAdultBirth CohortChildChild, PreschoolChinaFemaleHumansMalePregnancyThyrotropinThyroxineThyroid HormonesThyrotropinThyroxine

Identifiers

PMID41188611

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.