ReviewNature aging2025
A focus shift from sarcopenia to muscle health in the Asian Working Group for Sarcopenia 2025 Consensus Update.
Review in Nature aging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 163 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
163 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- The intervention effects of resistance exercise on sarcopenia in older adults: a systematic review and meta-analysis.BMC geriatrics · 2026Pooled it
- Effectiveness of Digital Health Interventions in Older Adults With Frailty and Sarcopenia: Systematic Review and Meta-Analysis of Randomized Controlled Trials.Journal of medical Internet research · 2026Pooled it
- Effects of SGLT2 inhibitors on body composition and potential sarcopenia-related outcomes in type 2 diabetes mellitus: a network meta-analysis.Frontiers in endocrinology · 2026Pooled it
- Trial
- [Effects of Blood Flow Restriction Training on Muscle Strength and Physical Function in Older Adults With Sarcopenia].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2026Trial
- [Effects of Exercise Training Combined With β-Hydroxy-β-Methylbutyrate Supplementation on Physical Function in Older Adults With Frailty].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2026Trial
- Response to letter regarding 'Bidirectional association of daily steps with sarcopenia: a longitudinal study'.Annals of medicine · 2026Article
- Regarding: "sarcopenia is a bad harbinger of cancer-related survival in rectal cancer".Annals of medicine · 2026Article
- Screening for sarcopenia risk using SARC-F and its relationship with laboratory parameters in primary care.Scandinavian journal of primary health care · 2026Article
- Response to letter regarding 'bidirectional association of daily steps with sarcopenia: a longitudinal study'.Annals of medicine · 2026Article
- Changes in Muscle Mass and the Risk of Liver-Related Events: A Prospective Cohort Study.Diabetes, obesity & metabolism · 2026Article
- Possible Sex Differences in the Morphological and Functional Muscle Quality Reflected by Phase Angle: Implications for Muscle Quality Assessment.Physiotherapy research international : the journal for researchers and clinicians in physical therapy · 2026Article
- Article
- Review
- Integrating Leg-Press Strength and Nutritional Status Improves 16-Year Mortality Risk Stratification in General Older Adults.Journal of cachexia, sarcopenia and muscle · 2026Article
- Optimizing frailty care: an analysis of dual exercise targets and cognitive function among frail older adults.GeroScience · 2026Article
- Consensus-Defined Sarcopenic Obesity and a Related Dynapenic Obesity Phenotype in Relation to Early Cognitive Impairment.Journal of cachexia, sarcopenia and muscle · 2026Article
- Article
- Low handgrip strength in advanced cancer: associated factors and clinical implications in palliative care.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026Article
- Two-wave status patterns of handgrip strength asymmetry and low handgrip strength in relation to all-cause mortality in middle-aged and older Chinese adults.GeroScience · 2026Article
103 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Asian Working Group for Sarcopenia (AWGS) presents an updated 2025 consensus reframing sarcopenia management through a life-course approach to muscle health promotion. While aligning with the Global Leadership Initiative in Sarcopenia (GLIS), this update provides healthcare providers with Asia-specific guidance. The consensus introduces three key refinements: first, expanding sarcopenia diagnosis to middle-aged adults (50‒64 years) with validated diagnostic thresholds; second, simplifying the diagnostic algorithm to require only concurrent low muscle mass and strength, with physical performance as an outcome measure; and third, introducing an enhanced muscle health framework recognizing skeletal muscle as vital for healthy longevity, emphasizing cross-talk with brain, bone, adipose tissue and immune systems. This framework leverages the World Health Organization's Integrated Care for Older People (ICOPE) implementation for enhanced case-finding through natural overlap between muscle health and ICOPE's intrinsic capacity domains. The consensus provides evidence-based recommendations for multimodal interventions that combine resistance exercise with nutritional supplementation, representing advancement toward proactive muscle health promotion and establishing a framework for reducing age-related decline in Asian populations.
Indexed as
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.