ArticleNature structural & molecular biology2025
Human DICER1 hotspot mutation induces both loss and gain of miRNA function.
Article in Nature structural & molecular biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed.
- DICER1-related tumour predisposition mutations increase 3p-miRNA function and HERVH activity.Nature communications · 2026Article
- Dicer Deletion in the Ear Can Cut Most Neurons and Their Innervation of Hair Cells to Project to the Ear and the Brainstem.International journal of molecular sciences · 2026Article
- Let-7 miRNAs are Selectively Sensitive to Dicer Dosage.microPublication biology · 2026Article
- DICER1 hotspot mutation induces 3p microRNA gain of function via Argonaute strand switch.Nature structural & molecular biology · 2025Article
- V-ATPase assembly at leaky lysosomes.Nature structural & molecular biology · 2025Article
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7 authors.
Funding
Abstract
The core miRNA biogenesis enzyme DICER1 sustains recurrent mutations in cancer that compromise its RNase IIIb domain, which cleaves 5p arms of precursor microRNA hairpins. However, the lack of knock-in models has limited fuller understanding. Here, we generated DICER1-knockout and DICER1
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.