Evidence map›Paper›PMID 41188566›Full record

ArticleBulletin of experimental biology and medicine2025

Prediction of Metabolic Profile and Virulence Factors of Facultative-Anaerobic Bacteria from Tuberculous Necrosis Foci Based on Whole-Genome Sequencing Data.

I G Kondratov, O B Ogarkov, V V Sinkov, A E Suzdalnitsky, M E Koshcheyev, E A Orlova, N L Belkova, S N Zhdanova, L V Rychkova, L I Kolesnikova

Abstract read
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In one paragraph

Article in Bulletin of experimental biology and medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

I G KondratovScientific Centre for Family Health and Human Reproduction Problems, Irkutsk, Russia.
O B OgarkovScientific Centre for Family Health and Human Reproduction Problems, Irkutsk, Russia. obogarkov@mail.ru.
V V SinkovScientific Centre for Family Health and Human Reproduction Problems, Irkutsk, Russia.
A E SuzdalnitskyIrkutsk Regional Clinical Tuberculosis Hospital, Irkutsk, Russia.
M E KoshcheyevIrkutsk Regional Clinical Tuberculosis Hospital, Irkutsk, Russia.
E A OrlovaScientific Centre for Family Health and Human Reproduction Problems, Irkutsk, Russia.
N L BelkovaScientific Centre for Family Health and Human Reproduction Problems, Irkutsk, Russia.
S N ZhdanovaScientific Centre for Family Health and Human Reproduction Problems, Irkutsk, Russia.
L V RychkovaScientific Centre for Family Health and Human Reproduction Problems, Irkutsk, Russia.
L I KolesnikovaScientific Centre for Family Health and Human Reproduction Problems, Irkutsk, Russia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Metagenomics of bacterial communities in tuberculosis caseous necrotic mass indicates the predominance of facultative anaerobes. Nine strains isolated from the tuberculosis necrosis were identified to species and whole-genome sequencing was performed: Staphylococcus hominis (3 strains), S. epidermidis (3 strains), Corynebacterium ureicelerivorans (2 strains), and C. kefirresidentii (1 strain). Prediction of metabolic pathways and virulence factors showed that Corynebacterium and Staphylococcus possess gene sets that are absent in Mycobacterium tuberculosis: lipases and proteases for the degradation of caseous necrosis, glutamate and polysaccharide capsules, ureases capable of increasing pH of the caseum; and Fe(III) uptake systems. The isolated species can form a bacterial consortium with M. tuberculosis at the early (Corynebacterium) and later (Staphylococcus) stages of necrotization of the tuberculosis focus in the lungs.

Indexed as

Bacteria, AnaerobicCorynebacteriumTuberculosisVirulence FactorsGenome, BacterialHumansMetabolomeMycobacterium tuberculosisNecrosisWhole Genome SequencingVirulence Factorscaseous necrosisMETABOLICsatellite microbiotaVFANALYZERwhole-genome sequencing

Identifiers

PMID41188566

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.