Evidence map›Paper›PMID 41188480›Full record

ArticleScientific reports2025

TGF-beta coordinates changes in Keratin gene expression during complex tissue regeneration.

Dipak D Meshram, Yuchang Liu, Molly Worth, Changqing Zhang, Tom J Carney, Henry H Roehl

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Dipak D MeshramSchool of Bioscience, The University of Sheffield, Firth Court, Western Bank, Sheffield, S10 2TN, UK.
Yuchang LiuSchool of Bioscience, The University of Sheffield, Firth Court, Western Bank, Sheffield, S10 2TN, UK.
Molly WorthSchool of Bioscience, The University of Sheffield, Firth Court, Western Bank, Sheffield, S10 2TN, UK.
Changqing ZhangLee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore.
Tom J CarneyLee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore.
Henry H RoehlSchool of Bioscience, The University of Sheffield, Firth Court, Western Bank, Sheffield, S10 2TN, UK. h.roehl@sheffield.ac.uk.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Zebrafish larval tail regeneration can be broadly broken down into three phases: wound repair, initiation of regeneration and redevelopment of the tail. We and others have shown that activation of the Hedgehog and TGF-beta signalling pathways is required to trigger tail regeneration. In this study we initially focus on these two pathways to better understand their role regeneration. We have found that Hedgehog signalling acts upstream of the TGF-beta pathway by activating transcription of the TGF-beta ligand tgfb1a. We have identified differentially expressed genes that are regulated after tail excision as well as those that are dependent upon TGF-beta signalling. From this analysis we found that Keratin genes fall into two categories of co-expression: one set that is upregulated by TGF-beta signalling after injury (krt

Indexed as

KeratinsRegenerationTransforming Growth Factor betaZebrafishZebrafish ProteinsAnimalsGene Expression RegulationGene Expression Regulation, DevelopmentalHedgehog ProteinsLarvaSignal TransductionTailWound HealingHedgehog ProteinsKeratinsTransforming Growth Factor betaZebrafish Proteins

Identifiers

PMID41188480
PMCPMC12586446

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.