ArticleScientific reports2025
Mentha spicata-mediated silver nanoparticles for combating Streptococcus mutans and oral cancer cells.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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3 citing papers in PubMed.
- Foliar application of green-synthesized Cu-Zn nanocomposites: improve physiological responses, isozymes activity, and photosynthetic traits in lead-stressed pea (Pisum sativum L.) plants.Scientific reports · 2026Article
- Phyto mediated synthesis of copper oxide nanoparticles with Zingiber officinale: comprehensive bioactivity assessment against bacterial pathogens, cancer, and viruses.BMC biotechnology · 2026Article
- Evaluation of antibacterial and cytotoxic effects of silver oxide nanoparticles synthesized from Psidium Guajava.Scientific reports · 2025Article
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9 authors.
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Abstract
A sustainable and ecologically safe substitute for traditional chemical synthesis, eco-friendly synthsis of silver nanoparticles (Ag-NPs) using plant-based extract offers promising biological opportunities. In this study, Ag-NPs were rapidly synthesized from an aqueous extract of Mentha spicata leaves and analyzed using a variety of techniques, including atomic force microscopy (AFM), transmission electron microscopy (TEM), zeta potential measurement, X-ray diffraction (XRD), UV-vis spectroscopy, and Fourier transform infrared spectroscopy (FTIR). Having a negative surface charge (- 32.5 mV) and an average width of 33 nm, the resultant nanoparticles were primarily spherical, indicating their colloidal stability. Streptococcus mutans ATCC 25175 was significantly inhibited by the antimicrobial evaluation, which revealed a minimum inhibitory concentration (MIC) of 0.125 mg/mL and a distinct inhibition zone of 20 mm. Planktonic growth was unaffected, however biofilm formation decreased by 77.3% (p < 0.05) at sub-MIC values (0.031 mg/mL). Computational docking further indicated potential interactions of Ag-NPs with dihydroorotase synthase and quorum sensing regulatory proteins, suggesting a mechanistic role in disrupting biofilm development. The nanoparticles also showed a high level of cytotoxicity against OECM-1 oral cancer cells, with an IC
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