Evidence map›Paper›PMID 41188408›Full record

Trial reportNature immunology2025

Peanut allergy oral immunotherapy drives single-cell multi-omic changes in peanut-reactive T cells associated with sustained unresponsiveness.

Xiaorui Han, Valeria Skatova, Artem Mikelov, Xuhuai Ji, Ramona A Hoh, Ji-Yeun Lee, Shu Cao, Hana Seastedt, Jackson Schuetz, Andrea Fernandes and 10 more

Abstract readClinical Trial, Phase II
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Nature immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Xiaorui HanSean N. Parker Center for Allergy and Asthma Research, Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA.ORCID http://orcid.org/0000-0002-9058-3363
Valeria SkatovaDepartment of Pathology, Stanford University School of Medicine, Stanford, CA, USA.
Artem MikelovDepartment of Pathology, Stanford University School of Medicine, Stanford, CA, USA.ORCID http://orcid.org/0000-0002-1629-2373
Xuhuai JiHuman Immune Monitoring Center, Institute for Immunity, Transplantation, and Infection, Stanford University School of Medicine, Stanford, CA, USA.ORCID http://orcid.org/0000-0002-1768-6403
Ramona A HohDepartment of Pathology, Stanford University School of Medicine, Stanford, CA, USA.
Ji-Yeun LeeDepartment of Pathology, Stanford University School of Medicine, Stanford, CA, USA.
Shu CaoSean N. Parker Center for Allergy and Asthma Research, Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA.
Hana SeastedtSean N. Parker Center for Allergy and Asthma Research, Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA.
Jackson SchuetzSean N. Parker Center for Allergy and Asthma Research, Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA.ORCID http://orcid.org/0000-0002-1053-2903
Andrea FernandesSean N. Parker Center for Allergy and Asthma Research, Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA.ORCID http://orcid.org/0000-0002-2855-4262
Arpita SinghalDepartment of Computer Science, School of Engineering, Stanford University, Stanford, CA, USA.
Fabian GrubertDepartment of Pathology, Stanford University School of Medicine, Stanford, CA, USA.
Rosemarie H DeKruyffSean N. Parker Center for Allergy and Asthma Research, Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA.
Holden T MaeckerHuman Immune Monitoring Center, Institute for Immunity, Transplantation, and Infection, Stanford University School of Medicine, Stanford, CA, USA.ORCID http://orcid.org/0000-0003-0795-9946
Stephen J GalliSean N. Parker Center for Allergy and Asthma Research, Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA.ORCID http://orcid.org/0000-0001-5736-5340
Monali ManoharSean N. Parker Center for Allergy and Asthma Research, Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA.
R Sharon Chinthrajah *Sean N. Parker Center for Allergy and Asthma Research, Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA. schinths@stanford.edu.ORCID http://orcid.org/0000-0003-2467-4256
Maya M Kasowski *Sean N. Parker Center for Allergy and Asthma Research, Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA. kasowski@stanford.edu.ORCID http://orcid.org/0000-0001-6583-0759
Scott D Boyd *Sean N. Parker Center for Allergy and Asthma Research, Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA. sboyd1@stanford.edu.ORCID http://orcid.org/0000-0003-0963-044X
Kari C Nadeau *Sean N. Parker Center for Allergy and Asthma Research, Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA. knadeau@hsph.harvard.edu.ORCID http://orcid.org/0000-0002-2146-2955

Funding

Tracking allergen specific T cells in multi-food allergyU19AI104209 · NIAID · STANFORD UNIVERSITY · PI GALLI, STEPHEN JOSEPH · 2013 to 2025
$17.3M
FUNCTIONAL ANALYSIS OF PATHOGENIC AND PROTECTIVE PEANUT ALLERGEN-SPECIFIC HUMAN ANTIBODIESR01AI125567 · NIAID · STANFORD UNIVERSITY · PI BOYD, SCOTT DEXTER · 2017 to 2022
$2.6M
NIAID NIH HHS R01 AI125567NIAID NIH HHS U19 AI104209U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (NIAID) R01AI125567U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (NIAID) U19AI104209
6 · The paper itself

Abstract

Oral immunotherapy (OIT) is the only U.S. Food and Drud Administration-approved treatment for peanut allergy. Peanut-reactive (pr) CD4

Indexed as

ArachisCD4-Positive T-LymphocytesDesensitization, ImmunologicPeanut HypersensitivityAdministration, OralAllergensChildFemaleHumansImmune ToleranceImmunophenotypingMaleMultiomicsSingle-Cell AnalysisTh2 CellsAllergens

Identifiers

PMID41188408
PMCPMC12643924

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.