ArticleScientific reports2025
Myoblast paracrine factors induce catabolic remodelling in electrically stimulated myotubes.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Skeletal muscle plasticity is strongly influenced by a multitude of cell populations within the muscle niche. Satellite cells, or resident muscle stem cells, play an essential role in skeletal muscle remodelling after injury where they differentiate into myoblasts and directly donate myonuclei to damaged fibres thereby promoting protein synthesis. Satellite cells have also been shown to act in a paracrine fashion to influence the infiltration of immune cells and other cell types into the skeletal muscle environment to advance regeneration. However, in many degenerative muscular conditions, satellite cell activity is impaired. Moreover, their paracrine mediated signalling directly to muscle fibres remains poorly understood, highlighting a promising therapeutic target for addressing satellite cell dysfunction. The purpose of this project was two-fold: (1) develop an in vitro model of myoblast (MBL) intercellular communication following myotube damage and (2) to determine if MBL proximity alone is adequate for improving tissue repair and reducing cellular stress during recovery. C
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