ArticleScientific reports2025
Patient derived xenograft models of hormone receptor positive and HER2 negative breast cancer from Indian patients.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
- Erratum issued
Authors and funding
20 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Limited success has been achieved in the development of patient-derived xenografts (PDX) models of hormone receptor-positive (HR+), Human Epidermal growth factor Receptor 2-negative (HER2-negative) metastatic breast cancers that are resistant to hormone therapy (HT). We aimed to establish and characterize PDX models from HR+/HER2-negative breast cancer. A total of 28 tumors were orthotopically implanted in the fourth mammary fat pad of female NOD-SCID mice. Seven PDXs were developed, five from heavily pretreated HT-resistant patients and two from treatment-naïve patients. Three of the seven PDXs (two from HT-resistant and one from treatment-naive) converted into lymphoma by generation 2 (G1). The median time for developing palpable G0 PDX was 100 (45-150) days for five HT-resistant tumors, and the mean time was 178 (160-196) days for two treatment-naïve tumors. Successful PDXs were developed from three HT-resistant tumors (two up to G4, one up to G0), including one of solid papillary morphology, and one treatment-naïve tumor (up to G2). Histopathological analyses showed complete concordance for all 14 PDX generations (11 resistant, 3 treatment-naïve) with their corresponding patient's tumor for estrogen receptor (ER), progesterone receptor (PR) and HER2. Short tandem repeat (STR) profiling using 18 markers was done in 8/11 HT-resistant generations and 3/3 treatment-naïve generations and showed good concordance of 51-100% and 91-100%, respectively, with patient tumors. We successfully established PDXs of HT-resistant and treatment-naïve HR+/HER2-negative breast cancer, which will be valuable tools for understanding molecular resistance mechanisms and for exploring novel treatment strategies.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.