Evidence map›Paper›PMID 41188273›Full record

ArticleNPJ Parkinson's disease2025

Cognitive function correlates with gastric alpha-synuclein seeding activity in early Parkinson's disease.

Chaewon Shin, Jong Pil Im, Jung-Youn Han, Bora Jin, Kyung Ah Woo, Seungmin Lee, HoYoung Jeon, Jae Young Joo, Hee Jin Chang, Jung Hwan Shin and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NPJ Parkinson's disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Chaewon ShinDepartment of Neurology, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam-si, Republic of Korea.
Jong Pil ImDivision of Gastroenterology, Department of Internal medicine, Seoul National University Hospital, Seoul National University College of Medicine and Liver Research Institute, Seoul, Republic of Korea.
Jung-Youn HanLaboratory Animal Center, Division of Research Strategy, Korea Brain Research Institute, Daegu, Republic of Korea.
Bora JinDepartment of Neurology, Dong-A University Hospital, Busan, Republic of Korea.
Kyung Ah WooDepartment of Neurology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Republic of Korea.
Seungmin LeeDepartment of Neurology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Republic of Korea.
HoYoung JeonDepartment of Neurology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Republic of Korea.
Jae Young JooDepartment of Neurology, Uijeongbu Eulji Medical Center, Uijeongbu, Republic of Korea.
Hee Jin ChangDepartment of Neurology, Chungnam National University Hospital, Chungnam National University College of Medicine, Daejeon, Republic of Korea.
Jung Hwan ShinDepartment of Neurology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Republic of Korea.
Han-Joon KimDepartment of Neurology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Republic of Korea.
Jong-Min KimDepartment of Neurology, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam-si, Republic of Korea.
Young Pyo ChoiLaboratory Animal Center, Division of Research Strategy, Korea Brain Research Institute, Daegu, Republic of Korea.
Beomseok JeonDepartment of Neurology, Chung-ang University Health Care System Hyundae Hospital, Namyangju-si, Republic of Korea. brain@snu.ac.kr.

Funding

Seoul National University Hospital 30-2022-0250
6 · The paper itself

Abstract

Alpha-synuclein (AS) accumulation is more frequently detected in the stomach than in the colon of patients with Parkinson's disease (PD), suggesting its potential as a pathologic biomarker. This study is to evaluate the diagnostic performance of real-time quaking-induced conversion assay on stomach biopsies for early PD and its association with clinical characteristics. Stomach biopsy tissues were prospectively collected from 22 patients with early-stage PD and 17 controls. Pathological AS-seeding activity was assessed, and correlations between kinematic parameters and clinical features were analyzed with age adjustment. Pathological AS-seeding activity was detected in 45.5% of patients with PD and in none of the controls. The Montreal Cognitive Assessment score was correlated with the lag time of positive replicates (Spearman's ρ = 0.742; p = 0.022), after age adjustment. The AS seed amplification assay using the stomach tissue may serve as a biomarker reflecting disease pathophysiology of the gut-brain axis in PD.

Identifiers

PMID41188273
PMCPMC12586573

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.