Evidence map›Paper›PMID 41188234›Full record

ArticleNature communications2025

Genetic exchange networks bridge mobile DNA vehicles in the bacterial pathogen Listeria monocytogenes.

Héloïse Muller, Odion O Ikhimiukor, Manuela Montoya-Giraldo, Kathryn R Piper, Maitiú Marmion, Seth L Blumerman, Lisa Mingle, Samantha E Wirth, Kimberlee A Musser, William J Wolfgang and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Héloïse MullerDepartment of Biological Sciences, State University of New York at Albany, Albany, New York, USA.ORCID http://orcid.org/0000-0001-5813-4229
Odion O IkhimiukorDepartment of Biological Sciences, State University of New York at Albany, Albany, New York, USA.ORCID http://orcid.org/0000-0002-3738-4584
Manuela Montoya-GiraldoDepartment of Biological Sciences, State University of New York at Albany, Albany, New York, USA.
Kathryn R PiperDepartment of Biological Sciences, State University of New York at Albany, Albany, New York, USA.
Maitiú MarmionDepartment of Biological Sciences, State University of New York at Albany, Albany, New York, USA.ORCID http://orcid.org/0000-0002-2246-1217
Seth L BlumermanWadsworth Center, New York State Department of Health, Albany, New York, USA.
Lisa MingleWadsworth Center, New York State Department of Health, Albany, New York, USA.
Samantha E WirthWadsworth Center, New York State Department of Health, Albany, New York, USA.ORCID http://orcid.org/0000-0002-7630-0128
Kimberlee A MusserWadsworth Center, New York State Department of Health, Albany, New York, USA.
William J WolfgangWadsworth Center, New York State Department of Health, Albany, New York, USA.ORCID http://orcid.org/0000-0003-1769-0215
Cheryl P AndamDepartment of Biological Sciences, State University of New York at Albany, Albany, New York, USA. candam@albany.edu.ORCID http://orcid.org/0000-0003-4428-0924

Funding

Population and evolutionary dynamics of recombining genes and alleles in bacteriaR35GM142924 · NIGMS · STATE UNIVERSITY OF NEW YORK AT ALBANY · PI Cheryl Marie P Andam · 2021 to 2026
$1.9M
FDA HHS U19 FD007089NCEZID CDC HHS U50 CK000423NIGMS NIH HHS R35 GM142924U.S. Department of Health & Human Services | Centers for Disease Control and Prevention (CDC) NU50CK000423U.S. Department of Health & Human Services | National Institutes of Health (NIH) R35GM142924U.S. Department of Health & Human Services | U.S. Food and Drug Administration (U.S. Food & Drug Administration) 1U19FD007089
6 · The paper itself

Abstract

Listeria monocytogenes (Lm) is an opportunistic foodborne pathogen responsible for gastrointestinal illnesses and life-threatening invasive infections. Antimicrobial resistance, virulence, and rapid adaptation to stressful environments in Lm lie in part on its mobile genetic elements (MGE). Here, we aim to characterize the MGE pool of a clinical Lm population using 936 genomes sampled across New York State (USA) from 2000 - 2021. We built a network based on sequence homology among putative MGEs. Within the network are communities of densely interconnected MGEs indicating high genetic similarity in their DNA regions. Although most connections involve the same MGE type, subsets within the network link different MGE types (plasmid-transposon, phage-plasmid). Phages and transposons did not share any genetic connections, suggesting impermeable barriers of exchange between them. Genes involved in stress tolerance are overrepresented in plasmids and transposons, and are mobile between vehicles. Analysis of long-read sequences of a subset of our dataset (n = 37) and publicly available, globally distributed complete genomes (n = 425) recapitulated the MGE connections we observed. Our findings reveal a structured but interconnected network of genetic exchanges between different mobile DNA vehicles. Genetic exchanges between MGEs shape Lm intra-species variation, adaptive potential, and rapid dissemination of clinically relevant traits at short timescales.

Indexed as

Interspersed Repetitive SequencesListeria monocytogenesBacteriophagesDNA, BacterialDNA Transposable ElementsGenome, BacterialHumansListeriosisNew YorkPlasmidsDNA, BacterialDNA Transposable Elements

Identifiers

PMID41188234
PMCPMC12586434

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.