Evidence map›Paper›PMID 41188221›Full record

ArticleNature communications2025

Chiral macrocycles forming high-affinity host-guest homoternary complexes for chiral discrimination and amplified circularly polarized luminescence.

Rong Fu, Fang-Yuan Chen, Le Dai, Dai-Yuan Li, Qing-Yu Zhao, Si-Dan Guo, Zi-Hang Song, Li-Bo Jing, Heng Wang, Xiaopeng Li and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Rong FuCollege of Chemistry, State Key Laboratory of Elemento-Organic Chemistry, Frontiers Science Center for New Organic Matter, Nankai University, Tianjin, China.
Fang-Yuan ChenCollege of Chemistry, State Key Laboratory of Elemento-Organic Chemistry, Frontiers Science Center for New Organic Matter, Nankai University, Tianjin, China.
Le DaiState Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China.
Dai-Yuan LiCollege of Chemistry, State Key Laboratory of Elemento-Organic Chemistry, Frontiers Science Center for New Organic Matter, Nankai University, Tianjin, China.
Qing-Yu ZhaoCollege of Chemistry, State Key Laboratory of Elemento-Organic Chemistry, Frontiers Science Center for New Organic Matter, Nankai University, Tianjin, China.
Si-Dan GuoCollege of Chemistry, State Key Laboratory of Elemento-Organic Chemistry, Frontiers Science Center for New Organic Matter, Nankai University, Tianjin, China.
Zi-Hang SongCollege of Chemistry, State Key Laboratory of Elemento-Organic Chemistry, Frontiers Science Center for New Organic Matter, Nankai University, Tianjin, China.
Li-Bo JingCollege of Chemistry, State Key Laboratory of Elemento-Organic Chemistry, Frontiers Science Center for New Organic Matter, Nankai University, Tianjin, China.
Heng WangState Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China.
Xiaopeng LiState Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China.
Dong-Sheng GuoCollege of Chemistry, State Key Laboratory of Elemento-Organic Chemistry, Frontiers Science Center for New Organic Matter, Nankai University, Tianjin, China.ORCID http://orcid.org/0000-0002-0765-5427
Kang CaiCollege of Chemistry, State Key Laboratory of Elemento-Organic Chemistry, Frontiers Science Center for New Organic Matter, Nankai University, Tianjin, China. kangcai@nankai.edu.cn.ORCID http://orcid.org/0000-0002-8883-0142

Funding

National Natural Science Foundation of China (National Science Foundation of China) 22271164National Natural Science Foundation of China (National Science Foundation of China) U20A20259
6 · The paper itself

Abstract

The development of macrocyclic hosts with high-affinity 1:2 recognition capabilities is crucial for advancing supramolecular chemistry and its applications. While cucurbit[8]uril (CB[8]) has long been recognized for its unparallel 1:2 binding affinity, its limitations-including poor solubility, difficulty to modify and lack of optical activity-have hindered broader utilization. Here, we introduce a class of enantiopure chiral macrocycles, RRRR- or SSSS-corral[4]BINOL (C[4]Bs), which exhibit remarkable 1:2 recognition properties in water that are comparable or even surpass CB[8]. Using UV-Vis, fluorometric, and isothermal titration calorimetry (ITC), we demonstrate that C[4]Bs form stable homoternary complexes with 11 singly positively charged planar aromatic guests, with binding affinities up to 10

Identifiers

PMID41188221
PMCPMC12586481

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.