ArticleChemphyschem : a European journal of chemical physics and physical chemistry2025
Dearomative Nucleophilic Addition of Lithium Enolates to Electron-Poor Indoles.
Article in Chemphyschem : a European journal of chemical physics and physical chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
1 citing paper in PubMed.
- Dearomative Nucleophilic Addition of Lithium Enolates to Electron-Poor Indoles.Chemphyschem : a European journal of chemical physics and physical chemistry · 2025Article
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Authors and funding
5 authors.
Funding
Abstract
The dearomatization of electron-poor indoles was investigated through the addition of lithiated ester or ketone enolates. Nitro-substituted indoles undergo 1,4-addition to afford the dearomatized products, after smooth hydrolysis. Indoles bearing an α-ketoamide group show a more complex reactivity, undergoing either 1,2- or 1,4-addition, depending on the steric hindrance of the amide group. The regioselectivity of the latter is buttressed by DFT calculations.
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Registered trials
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