ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2025
Structural Plasticity of Peptidergic and Nonpeptidergic C Afferent Terminals in the Medullary Dorsal Horn during Craniofacial Inflammatory Pain.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Integrative Analysis Reveals Interactions Between Gut Microbiota-Derived Metabolites and the Brain in Parkinson's Disease.Molecular neurobiology · 2026Article
- Neurodegenerative Disease Movement Disorders and Dorsal Striatum-Mediated Imbalance of Habitual Motor Sequences.Molecular neurobiology · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nociceptive afferents and dorsal horn neurons undergo significant functional changes in pathological pain conditions. The structural remodeling of synapses of C afferents, which may contribute to the long-term maintenance of these changes, is not well understood. To investigate this issue, we used quantitative immuno-electron microscopy with serial sections to examine the structural changes of calcitonin gene-related peptide (CGRP)-immunopositive (+) and isolectin-B4+ (IB4+) axon terminals (boutons) and their pre- and postsynaptic elements in the rat medullary dorsal horn (MDH, trigeminal caudal nucleus). The study was conducted at 4 d (CFA 4-day) and 21 d (CFA 21-day) following complete Freund's adjuvant (CFA) injection into the vibrissa pad of the male Sprague Dawley rats, when thermal hyperalgesia was severe and had recovered, respectively. The ultrastructural parameters correlated with synaptic strength (bouton volume, mitochondrial volume, docked vesicle number, postsynaptic density area, dendritic spine number and size) in CGRP+ and IB4+ boutons and their postsynaptic dendrites increased significantly in the CFA 4-day group compared with control. The fraction of IB4+ boutons receiving axoaxonic synapses and the number of GAD65/67+ boutons involved in pre- and postsynaptic inhibition decreased significantly in the CFA 4-day group compared with control; these changes were restored to control levels in the CFA 21-day group. These structural changes in the C afferents and their pre- and postsynaptic elements in the MDH following inflammation may provide the morphological basis for the development and long-term maintenance of craniofacial inflammatory pain.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.