Evidence map›Paper›PMID 41188028›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2025

Too Little and Too Much: Balanced Hippocampal, But Not Medial Prefrontal, Neural Activity Is Required for Intact Novel Object Recognition in Rats.

Charlotte J L Taylor, Jacco G Renström, Joanna Loayza, Miriam Gwilt, Stuart A Williams, Rachel Grasmeder Allen, Paula M Moran, John Gigg, Joanna Neill, Michael Harte and 1 more

Abstract read
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In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Charlotte J L TaylorSchool of Psychology and Neuroscience@Nottingham, University of Nottingham, Nottingham NG7 2RD, United Kingdom charlie.taylor@nottingham.ac.uk tobias.bast@nottingham.ac.uk.
Jacco G RenströmSchool of Psychology and Neuroscience@Nottingham, University of Nottingham, Nottingham NG7 2RD, United Kingdom.
Joanna LoayzaSchool of Psychology and Neuroscience@Nottingham, University of Nottingham, Nottingham NG7 2RD, United Kingdom.
Miriam GwiltSchool of Psychology and Neuroscience@Nottingham, University of Nottingham, Nottingham NG7 2RD, United Kingdom.
Stuart A WilliamsSchool of Psychology and Neuroscience@Nottingham, University of Nottingham, Nottingham NG7 2RD, United Kingdom.
Rachel Grasmeder AllenSchool of Psychology and Neuroscience@Nottingham, University of Nottingham, Nottingham NG7 2RD, United Kingdom.
Paula M MoranSchool of Psychology and Neuroscience@Nottingham, University of Nottingham, Nottingham NG7 2RD, United Kingdom.
John GiggDivision of Neuroscience, University of Manchester, Manchester M13 9PT, United Kingdom.
Joanna NeillDivision of Pharmacy and Optometry, University of Manchester, Manchester M13 9PT, United Kingdom.
Michael HarteDivision of Pharmacy and Optometry, University of Manchester, Manchester M13 9PT, United Kingdom.
Tobias BastSchool of Psychology and Neuroscience@Nottingham, University of Nottingham, Nottingham NG7 2RD, United Kingdom charlie.taylor@nottingham.ac.uk tobias.bast@nottingham.ac.uk.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Impaired GABAergic inhibition, so-called neural disinhibition, in the prefrontal cortex and hippocampus has been linked to cognitive deficits. The novel object recognition (NOR) task has been used widely to study cognitive deficits in rodents. However, the contribution of prefrontal cortical and hippocampal GABAergic inhibition to NOR task performance has not been established. Here, we investigated NOR task performance in male Lister hooded rats following regional neural disinhibition or functional inhibition, using intracerebral microinfusion of the GABA

Indexed as

HippocampusNeural InhibitionPrefrontal CortexRecognition, PsychologyAnimalsGABA-A Receptor AgonistsMaleMuscimolPicrotoxinRatsGABA-A Receptor AgonistsMuscimolPicrotoxinGABAhippocampusinhibitionNORprefrontal cortex

Identifiers

PMID41188028
PMCPMC12696617

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.