Evidence map›Paper›PMID 41188020›Full record

ArticleLife science alliance2026

Aberrant NSUN1 activity connects m

Melissa Parra-Torres, Kumara Dissanayake, James A Gray, Alistair J Langlands, Ridvan Kucuk, Marek Gierlinski, Claire Troakes, Andrew King, Leeanne McGurk

Abstract read
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In one paragraph

Article in Life science alliance, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Melissa Parra-TorresDivision of Molecular, Cell and Developmental Biology, School of Life Sciences, University of Dundee, Dundee, UK.ORCID 0009-0007-6093-7435
Kumara DissanayakeDivision of Molecular, Cell and Developmental Biology, School of Life Sciences, University of Dundee, Dundee, UK.
James A GrayDivision of Molecular, Cell and Developmental Biology, School of Life Sciences, University of Dundee, Dundee, UK.ORCID 0009-0008-2096-7266
Alistair J LanglandsNational Phenotypic Screening Centre, School of Life Sciences, University of Dundee, Dundee, UK.ORCID 0009-0001-6675-2745
Ridvan KucukDivision of Molecular, Cell and Developmental Biology, School of Life Sciences, University of Dundee, Dundee, UK.
Marek GierlinskiData Analysis Group, Division of Computational Biology, School of Life Sciences, University of Dundee, Dundee, UK.ORCID 0000-0001-9149-3514
Claire TroakesDepartment of Basic and Clinical Neuroscience, London Neurodegenerative Diseases Brain Bank, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Andrew KingKing's College Hospital NHS Foundation Trust, Academic Neuroscience Centre, London, UK.ORCID 0000-0002-7974-2589
Leeanne McGurkDivision of Molecular, Cell and Developmental Biology, School of Life Sciences, University of Dundee, Dundee, UK LMcgurk001@dundee.ac.uk.ORCID 0000-0002-6493-6751

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), the nuclear RNA-binding protein TDP-43 mislocalises to the cytoplasm and forms insoluble aggregates, but the mechanisms controlling this remain unclear. We define a native TDP-43 interactome in human SH-SY5Y cells and identify proteins linked to the 5-methylcytosine (m

Indexed as

5-MethylcytosineAmyotrophic Lateral SclerosisDNA-Binding ProteinsFrontotemporal DementiaMethyltransferasesRNAAnimalsCell Line, TumorDisease Models, AnimalDrosophilaDrosophila melanogasterDrosophila ProteinsHumansMethylation5-MethylcytosineDNA-Binding ProteinsDrosophila ProteinsMethyltransferasesRNATARDBP protein, human

Identifiers

PMID41188020
PMCPMC12588883

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.