ReviewAmerican journal of physiology. Heart and circulatory physiology2025
Extracellular vesicles in preeclampsia: drivers of vascular dysfunction and inflammation.
Review in American journal of physiology. Heart and circulatory physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed.
- The Immunopathology of Preeclampsia.Biomedicines · 2026Review
- Endothelial Dysfunction in Preeclampsia: Focus on the Uteroplacental Circulation.Arteriosclerosis, thrombosis, and vascular biology · 2026Review
- Macrophage membrane-biomimetic nanovehicles delivering amygdalin halt pyroptosis propagation and alleviate endometriosis-associated neuropathic pain.Materials today. Bio · 2026Article
- Extracellular Vesicles in the Gut-Vascular-Brain Axis: A Missing Mechanistic Link Between IBD and Stroke Risk.Biomolecules · 2026Review
- Extracellular Vesicle-Associated Non-Coding RNAs in Preeclampsia: Mechanistic Insights, Biomarker Discovery, and Emerging Nanomedicine Concepts.International journal of nanomedicine · 2026Review
- Crosstalk of extracellular vesicles in maternal-fetal interaction.Frontiers in cell and developmental biology · 2026Review
- Premature placental senescence in early-onset preeclampsia: syncytiotrophoblast SASP and the maternal syndrome.Frontiers in public health · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Vascular inflammation, augmented vasoconstriction, reduced vasodilatory capacity, and endothelial dysfunction are cardinal features of the maternal vascular dysfunction phenotype in preeclampsia. Extracellular vesicles (EVs), bioactive molecules loaded with proteins, glycans, lipids, and nucleic acids facilitate intracellular signaling and cell-to-cell cross talk. Circulating EV concentrations rise throughout normal pregnancy; however, preeclampsia is characterized by a further increase in multiple types of EVs and a shift toward a proinflammatory, vasoactive cargo. Emerging evidence suggests that in preeclampsia, circulating EVs activate maternal endothelial cells, propagate vascular inflammation, and impair vascular tone and endothelial integrity, contributing to the development of hypertension and excess vasoconstriction. This review briefly introduces fundamental knowledge about EV biogenesis, morphology, and cargo selection, then focuses on current evidence on EV-induced endothelial inflammation and vascular dysfunction in pregnancies with preeclampsia versus uncomplicated pregnancies. Finally, we discuss the therapeutic potential of engineered or stem cell-derived EVs to restore maternal vascular health in preeclampsia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.