Evidence map›Paper›PMID 41187975›Full record

ArticleEquine veterinary journal2026

Field-applicable low-intensity exercise induces bronchodilation in horses with severe asthma.

Sophie Mainguy-Seers, Sarah-Maude Grondin, Jean-Pierre Lavoie

Abstract read
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Article in Equine veterinary journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

3 authors.

Sophie Mainguy-SeersDepartment of Clinical Sciences, Faculty of Veterinary Medicine, Université de Montréal, Saint-Hyacinthe, Quebec, Canada.ORCID https://orcid.org/0000-0002-4768-6674
Sarah-Maude GrondinDepartment of Clinical Sciences, Faculty of Veterinary Medicine, Université de Montréal, Saint-Hyacinthe, Quebec, Canada.
Jean-Pierre LavoieDepartment of Clinical Sciences, Faculty of Veterinary Medicine, Université de Montréal, Saint-Hyacinthe, Quebec, Canada.ORCID https://orcid.org/0000-0003-4655-2102

Funding

Equine Asthma Research Laboratory
6 · The paper itself

Abstract

backgroundAirway dysfunction in severe equine asthma (SEA) often results in early retirement or euthanasia of affected horses. Exercise-induced bronchodilation occurs in horses with SEA after intense treadmill exercise, but the effects of a lighter, field-applicable, training regimen remain largely unexplored.

objectivesTo evaluate the impact of submaximal aerobic exercise on airway obstruction during exacerbation of SEA. STUDY

designThe preliminary phase explored the effects of a 25-min standardised exercise on the lung function of eight SEA horses. As notable bronchodilation occurred, the results were confirmed in a randomised controlled crossover protocol comparing the effect of the same standardised exercise on lung function with that of an equal duration turnout.

methodsLung function was assessed by standard lung mechanics before and 15 min after the interventions (turnout and walk/trot lungeing exercise). To compare exercise-induced bronchodilation with that of a potent bronchodilator in the main study, salbutamol was administered after the turnout intervention only, and lung function was measured again 5 min later. Data were analysed with t tests, Wilcoxon tests, and mixed-effects models.

resultsIn the preliminary phase, exercise led to a mean 50% reduction in pulmonary resistance. This was confirmed in the main study, where pulmonary resistance decreased from 2.6 (2.1-3.3) to 1.3 cm (0.8-2.2) H MAIN LIMITATIONS: The small number of aged horses, the lack of blinding, and the focus on the short-term effects of exercise restrict the generalisability of the results.

conclusionsThe rapid and potent bronchodilation achieved through brief aerobic exercise supports the investigation of a training program's impact on the management of SEA.

Indexed as

AsthmaBronchodilator AgentsHorse DiseasesPhysical Conditioning, AnimalAlbuterolAnimalsCross-Over StudiesFemaleHorsesMaleAlbuterolBronchodilator Agentsheaveshorselung functionphysical trainingsalbutamolβ2‐adrenergic agonist

Identifiers

PMID41187975
PMCPMC13447923

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.