ArticleCell reports methods2025
A tabletop blast device for the study of the long-term consequences of traumatic brain injury on brain organoids.
Article in Cell reports methods, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed.
- Translational benchmarking of 3D in vitro models of traumatic brain injury.Trends in biotechnology · 2026Review
- A 3D Human Neuron-on-Chip Platform to Monitor Neuronal Injury Responses.Advanced healthcare materials · 2026Article
- Modeling Epilepsies with Human Brain Organoids: Recent Advances and Ongoing Challenges.Epilepsy currents · 2026Review
- Focused ultrasound-induced cavitation in a human brain microphysiological system produces injury signaling biomarkers consistent with blast trauma.npj biomedical innovations · 2026Article
- Neuroglial Response to High-Amplitude, Short-Duration Pressure Transients in Monoculture.Cell biochemistry and function · 2026Article
- Engineering Brain Injury In Vitro: Human iPSC-Based Organoids in Microfluidic Systems.Applied sciences (Basel, Switzerland) · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Traumatic brain injury (TBI) is the leading environmental risk factor for neurodegenerative diseases, yet its molecular link to chronic neurodegeneration is unclear. While animal models of TBI are commonly used, emerging research suggests that induced pluripotent stem cell (iPSC)-derived brain organoids offer a promising human-specific alternative, particularly for studying processes like cryptic exon splicing. However, widespread use has been limited by methodological variability and the need for expensive and specialized equipment. To address these challenges, we developed a tabletop blast device capable of delivering highly reproducible pressure waves via a gravity-based pressure chamber. We validated the applicability of our approach by assessing the short- and long-term consequences of mechanical stress on brain organoids after pressure wave exposure. Our approach provides a controllable and reproducible method to apply complex pressure cycles on brain organoids, enabling broader accessibility for studying the mechanistic links between TBI and neurodegeneration in a human-relevant context.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.