Evidence map›Paper›PMID 41187746›Full record

ArticleCell stem cell2025

Senolytic-sensitive p16

Jin Young Lee, Nabora Reyes, Sang-Ho Woo, Nancy C Allen, Tsukasa Kadota, Andrew Lechner, Ritusree Biswas, Sakshi Goel, Fia Stratton, Chaoyuan Kuang and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell stem cell, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors.

Jin Young LeeDepartment of Medicine, Division of Pulmonary, Critical Care, Allergy and Sleep Medicine, University of California, San Francisco, San Francisco, CA 94143, USA; Bakar Aging Research Institute, University of California, San Francisco, San Francisco, CA 94143, USA; Department of Physiology and Biophysics, College of Medicine, Inha University, Incheon 22212, Republic of Korea. Electronic address: jinyoung.lee@inha.ac.kr.
Nabora ReyesDepartment of Medicine, Division of Pulmonary, Critical Care, Allergy and Sleep Medicine, University of California, San Francisco, San Francisco, CA 94143, USA; Bakar Aging Research Institute, University of California, San Francisco, San Francisco, CA 94143, USA; Cell and Developmental Biology, School of Biological Sciences, University of California, San Diego, San Diego, CA 92093, USA.
Sang-Ho WooDepartment of Medicine, Division of Pulmonary, Critical Care, Allergy and Sleep Medicine, University of California, San Francisco, San Francisco, CA 94143, USA; Bakar Aging Research Institute, University of California, San Francisco, San Francisco, CA 94143, USA.
Nancy C AllenDepartment of Medicine, Division of Pulmonary, Critical Care, Allergy and Sleep Medicine, University of California, San Francisco, San Francisco, CA 94143, USA; Bakar Aging Research Institute, University of California, San Francisco, San Francisco, CA 94143, USA.
Tsukasa KadotaDepartment of Medicine, Division of Pulmonary, Critical Care, Allergy and Sleep Medicine, University of California, San Francisco, San Francisco, CA 94143, USA; Bakar Aging Research Institute, University of California, San Francisco, San Francisco, CA 94143, USA.
Andrew LechnerDepartment of Medicine, Division of Pulmonary, Critical Care, Allergy and Sleep Medicine, University of California, San Francisco, San Francisco, CA 94143, USA; Bakar Aging Research Institute, University of California, San Francisco, San Francisco, CA 94143, USA.
Ritusree BiswasDepartment of Medicine, Division of Pulmonary, Critical Care, Allergy and Sleep Medicine, University of California, San Francisco, San Francisco, CA 94143, USA; Bakar Aging Research Institute, University of California, San Francisco, San Francisco, CA 94143, USA.
Sakshi GoelAlbert Einstein Cancer Center, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Fia StrattonAlbert Einstein Cancer Center, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Chaoyuan KuangAlbert Einstein Cancer Center, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Tatsuya TsukuiDepartment of Medicine, Division of Pulmonary, Critical Care, Allergy and Sleep Medicine, University of California, San Francisco, San Francisco, CA 94143, USA.
Vincent AuyeungDepartment of Medicine, Division of Pulmonary, Critical Care, Allergy and Sleep Medicine, University of California, San Francisco, San Francisco, CA 94143, USA.
Aaron S MansfieldDepartment of Oncology, Division of Medical Oncology, Mayo Clinic, Rochester, MN 55905, USA.
Lindsay M LaFaveAlbert Einstein Cancer Center, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Tien PengDepartment of Medicine, Division of Pulmonary, Critical Care, Allergy and Sleep Medicine, University of California, San Francisco, San Francisco, CA 94143, USA; Bakar Aging Research Institute, University of California, San Francisco, San Francisco, CA 94143, USA. Electronic address: tien.peng@ucsf.edu.

Funding

UC San Diego FIRST ProgramU54CA272220 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI VIVIAN REZNIK · 2022 to 2026
$21.2M
Defining the resident mesenchymal stem cell niche and function in vivoDP2AG056034 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI PENG, TIEN · 2016 to 2016
$2.4M
Deciphering the role of p16INK4A+ fibroblasts in lung fibrosisR01HL160895 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI PENG, TIEN · 2022 to 2025
$2.2M
IRE1α mediated dysregulation of the pulmonary epithelium in lung fibrosisK08HL157654 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI AUYEUNG, VINCENT CHURK-MAN · 2021 to 2025
$874k
NCI NIH HHS U54 CA272220NHLBI NIH HHS K08 HL157654NHLBI NIH HHS R01 HL160895NIA NIH HHS DP2 AG056034
6 · The paper itself

Abstract

Senescence has been demonstrated to either inhibit or promote tumorigenesis. Resolving this paradox requires spatial mapping and functional characterization of senescent cells in the native tumor niche. Here, we identify p16

Indexed as

Cancer-Associated FibroblastsCell PlasticityCyclin-Dependent Kinase Inhibitor p16FibroblastsLung NeoplasmsAdenocarcinoma of LungAnimalsCell Line, TumorCellular SenescenceHumansMiceStromal CellsTumor MicroenvironmentCyclin-Dependent Kinase Inhibitor p16cancer-associated fibroblastslung adenocarcinomap16(INK4a)senescencesenolyticsspatial transcriptomicstumor cell plasticitytumor metabolismtumor microenvironment

Identifiers

PMID41187746
PMCPMC13186318

What OpenQuestion holds

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Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.