Evidence map›Paper›PMID 41186899›Full record

Trial reportBiological trace element research2026

A Modified Iodine Balance Study to Explore the Recommended Nutrient Intake of Iodine in Chinese Preschool Children Aged 3 to 6 Years.

Rui Yang, Qi Jin, Dong An, Dongping Lv, Yidan Wei, Elizabeth N Pearce, Junhong Yang, Dongmei Meng, Jiayi Zhang, Weiwei Gao and 1 more

Abstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Biological trace element research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

11 authors.

Rui YangDepartment of Nutrition and Food Hygiene, School of Public Health, Tianjin Medical University, Tianjin, China.
Qi JinDepartment of Nutrition and Food Hygiene, School of Public Health, Tianjin Medical University, Tianjin, China.
Dong AnTianjin Children's Hospital (Tianjin University Children's Hospital), Tianjin, China.
Dongping LvDepartment of Nutrition and Food Hygiene, School of Public Health, Tianjin Medical University, Tianjin, China.
Yidan WeiDepartment of Nutrition and Food Hygiene, School of Public Health, Tianjin Medical University, Tianjin, China.
Elizabeth N PearceSection of Endocrinology, Diabetes, and Nutrition, Boston University School of Medicine, Boston, MA, USA.
Junhong YangTianjin Children's Hospital (Tianjin University Children's Hospital), Tianjin, China.
Dongmei MengTianjin Children's Hospital (Tianjin University Children's Hospital), Tianjin, China.
Jiayi ZhangTianjin Children's Hospital (Tianjin University Children's Hospital), Tianjin, China.
Weiwei GaoTianjin Children's Hospital (Tianjin University Children's Hospital), Tianjin, China.
Wen ChenDepartment of Nutrition and Food Hygiene, School of Public Health, Tianjin Medical University, Tianjin, China. wenchen@tmu.edu.cn.

Funding

National Natural Science Foundation of China NSFC Grant No.82273629the Tianjin Key Laboratory of Environment, Nutrition, and Public Health 2020ENKL01
6 · The paper itself

Abstract

The recommended nutrient intakes (RNI) for iodine in preschool children in China are outdated. The study aimed to establish optimal iodine intake for Chinese preschool children aged 3-6 years using a modified iodine balance methodology. During the 3-day iodine balance study, 75 healthy preschool children aged 3-6 years were randomly divided into three groups. Dietary interventions were applied to bal-ance the proportion of children with positive and negative iodine balance across groups. All food items consumed and excreta (urine, feces) were systematically col-lected to analyze the relationships among daily iodine intake, excretion, and retention. A total of 42 children (56.0%) were in negative iodine balance, while 33 children (44.0%) were in positive iodine balance. The zero iodine balance value (defined as the iodine intake level at which intake equals excretion) among the three groups increased with higher iodine intake. A significant positive association was observed between iodine intake and iodine excretion (β: 0.45; 95% CI: 0.30, 0.60; P < 0.001), with an obligatory iodine excretion of 36 μg/d. Additionally, iodine intake was significantly associ-ated with increased iodine retention (β: 0.55; 95% CI: 0.40, 0.70; P < 0.001). The zero io-dine balance value for preschool children aged 3-6 years was determined to be 65.6 μg/d. Our study estimated the estimated average requirement (EAR) for iodine in preschool children aged 3-6 years in China to be 65.6 μg/d, and the calculated RNI is 90 μg/d. Our study provides critical data support for establishing China's dietary reference intakes for iodine.

Indexed as

IodineRecommended Dietary AllowancesChildChild, PreschoolChinaEast Asian PeopleFemaleHumansMaleNutritional StatusIodineChinaDietary reference intakesIodine-balance studyIodine requirementPreschool children

Identifiers

PMID41186899

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.