Evidence map›Paper›PMID 41186872›Full record

ArticleDiscover oncology2025

Causal relationship between oral/gut microbiota and lung cancer: a two-sample Mendelian randomization study.

Zi-Jian Huang, Lv Wu, Ying-Long Peng, Zhi-Hong Chen, Chong-Rui Xu, Yu Deng, Hong-Hong Yan, Chang Lu, Qing Zhou

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Discover oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Zi-Jian Huang *Guangdong Lung Cancer Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, 510,080, China.
Lv Wu *Guangdong Lung Cancer Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, 510,080, China.
Ying-Long Peng *Guangdong Lung Cancer Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, 510,080, China.
Zhi-Hong ChenGuangdong Lung Cancer Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, 510,080, China.
Chong-Rui XuGuangdong Lung Cancer Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, 510,080, China.
Yu DengGuangdong Lung Cancer Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, 510,080, China.
Hong-Hong YanGuangdong Lung Cancer Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, 510,080, China.
Chang LuGuangdong Lung Cancer Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, 510,080, China. luchang@gdph.org.cn.
Qing ZhouGuangdong Lung Cancer Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, 510,080, China. gzzhouqing@126.com.

Funding

Guangdong Provincial Science and Technology Planning Project Grant No. 2023B110009Guangzhou Science and Technology Program Grant No. 2025A03J4506MOE Changjiang Distinguished Professor Supporting Project Grant No. KY0120240205the National Natural Science Foundation of China Grant No. 82303643the National Natural Science Foundation of China Grant No. 82373349
6 · The paper itself

Abstract

purposeSeveral studies have already proven a significant correlation between the microbiota and lung cancer. In this study, we explore the potential relative oral and gut microbiota which influence the risk of lung cancer.

methodsWe utilized genome-wide association study (GWAS) data from oral microbiota (2984 healthy individuals) and gut microbiota (2002 healthy individuals) and lung cancer with a two-sample Mendelian randomization (MR) analysis method. In this analysis, oral microbiota and gut microbiota were conducted as exposure. Lung cancer data obtained from GWAS including a total of 212,453 individuals. Inverse-variance weighted (IVW) method was used as the primary method.

resultsIVW analysis identified that genus Pauljensenia, Capnocytophaga and Aggregatibacter in oral microbiota are potentially protective against lung cancer. On the contrary, higher abundances of bacteria within the genus Granulicatella, Streptococcus, Saccharimonadaceae TM7x and Neisseria in oral microbiota were associated with increased lung cancer risk. Among gut bacteria, species Enterococcus faecalis were positively associated with an increased risk of lung cancer.

conclusionThe findings of this study suggest a potential causal relationship between distinct oral and gut microbial communities and lung cancer risk, offering valuable insights into microbial candidates that may serve as targets for future diagnostic innovations.

Indexed as

Gut microbiotaLung cancerMendelian randomizationOral microbiotaSingle nucleotide polymorphism

Identifiers

PMID41186872
PMCPMC12586745

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.