Evidence map›Paper›PMID 41186846›Full record

ArticlePhotochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology2025

Combining NAD(P)H-FLIM and PLIM of Ir5 pH sensor to optimize photodynamic therapy through metabolic intracellular pattern segmentation.

D Dos Santos, K Reess, N Naskar, I S Kritchenkov, S P Tunik, A Rueck

Abstract read
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In one paragraph

Article in Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

D Dos SantosUniversity Ulm ZBMF, Helmholtzstrasse 8/1, 89081, Ulm, Germany. daniela.santos@uni-ulm.de.
K ReessUniversity Ulm Core Facility Confocal and Multiphoton Microscopy N24, Albert-Einstein-Allee 11, 89081, Ulm, Germany.
N NaskarUniversity Ulm Core Facility Confocal and Multiphoton Microscopy N24, Albert-Einstein-Allee 11, 89081, Ulm, Germany.
I S KritchenkovInstitute of Chemistry, Saint-Petersburg State University , Universitetskii pr 26, St. Petersburg, Russia, 198504.
S P TunikInstitute of Chemistry, Saint-Petersburg State University , Universitetskii pr 26, St. Petersburg, Russia, 198504.
A RueckUniversity Ulm ZBMF, Helmholtzstrasse 8/1, 89081, Ulm, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Metabolic Fluorescence Lifetime Imaging Microscopy (FLIM) algorithms have become invaluable tools for exploring deep into the complex dynamics of cellular metabolism. Monitoring subcellular parameters is of interest, particularly during photodynamic therapy (PDT), to enhance treatment efficacy. By joining together Metabolic FLIM with PLIM, it is possible to evaluate cellular metabolic states, such as oxygen consumption, redox states, pH levels, and energy production pathways. The aim of this work is to use NADH FLIM and PLIM techniques to distinguish different metabolic pattern signatures in tumor and normal cell lines using a PLIM pH sensitive complex from the family of phosphorescent [(N^C)

Indexed as

NADNADPPhotochemotherapyPhotosensitizing AgentsCell Line, TumorHumansHydrogen-Ion ConcentrationMicroscopy, FluorescenceOptical ImagingNADNADPPhotosensitizing AgentsMetabolic FLIMMetabolic pattern segmentationPDTPLIMTCSPC

Identifiers

PMID41186846

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.