Evidence map›Paper›PMID 41186821›Full record

ArticleBulletin of experimental biology and medicine2025

Impact of Female Sex Hormones on the Expression of CCR5/CCR8 Co-Receptor Genes and Virus Replication in HIV-1 Infection.

M N Nosik, E P Bystritskaya, K A Ryzhov, E V Berezhnaya, O A Lobach, I A Kiseleva, D E Kireev, A V Kuzina, E P Kostyuchenko, V E Vasileva and 2 more

Abstract read
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Article in Bulletin of experimental biology and medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

M N NosikI. Mechnikov Research Institute of Vaccines and Sera, Moscow, Russia.
E P BystritskayaI. Mechnikov Research Institute of Vaccines and Sera, Moscow, Russia. lisabystritskaya@gmail.com.
K A RyzhovI. Mechnikov Research Institute of Vaccines and Sera, Moscow, Russia.
E V BerezhnayaI. Mechnikov Research Institute of Vaccines and Sera, Moscow, Russia.
O A LobachI. Mechnikov Research Institute of Vaccines and Sera, Moscow, Russia.
I A KiselevaI. Mechnikov Research Institute of Vaccines and Sera, Moscow, Russia.
D E KireevCentral Research Institute of Epidemiology, Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing, Moscow, Russia.
A V KuzinaI. M. Sechenov First Moscow State Medical University, Ministry of Health of the Russian Federation (Sechenov University), Moscow, Russia.
E P KostyuchenkoI. M. Sechenov First Moscow State Medical University, Ministry of Health of the Russian Federation (Sechenov University), Moscow, Russia.
V E VasilevaPirogov Russian National Research Medical University (Pirogov University), Ministry of Health of the Russian Federation, Moscow, Russia.
A A ZiminaI. M. Sechenov First Moscow State Medical University, Ministry of Health of the Russian Federation (Sechenov University), Moscow, Russia.
O A SvitichI. Mechnikov Research Institute of Vaccines and Sera, Moscow, Russia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We studied the effects of female sex hormones estradiol and progesterone on the expression of CCR5 and CCR8 co-receptor genes (that play an important role in the HIV-1 entry into the cell) in human peripheral blood mononuclear cells (PBMC) isolated from different female donors and infected with HIV-1 subtype G. Female sex hormones produced a dose-dependent effect on the replication of HIV-1 subtype G: low doses of estradiol and high doses of progesterone significantly induced CCR8 expression in PBMC of all donors, which correlated with an increase in viral load by 1.5-1.7 times on average. The exception was one donor, in whom a high dose of estradiol also induced an increase in CCR8 expression. High concentrations of progesterone also enhanced the expression of the CCR5 co-receptor. The detected differences in the co-receptor expression in infected PBMC from different donors indicates that the host genetics may also play an important role in PBMC susceptibility to HIV infection.

Indexed as

EstradiolHIV-1HIV InfectionsProgesteroneReceptors, CCR5Virus ReplicationAdultFemaleHumansLeukocytes, MononuclearViral LoadCCR5 protein, humanEstradiolProgesteroneReceptors, CCR5CCR5 co-receptorCCR8 co-receptorestradiolHIV-1progesterone

Identifiers

PMID41186821

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.