ArticleBiotechnology letters2025
Ultrasonic high efficiency preparation of arctigenin from the fruits of Arctium lappa L using Aspergillus niger with deep eutectic solvent assisted.
Article in Biotechnology letters, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Arctigenin, a high-value lignan with broad bioactivities, suffers from low yield in conventional extraction. This study developed a green and efficient process integrating natural deep eutectic solvent (NADES)-pretreated Aspergillus niger fermentation with ultrasound-assisted extraction. Under optimized conditions (liquid-solid ratio 26:1 mL/g, 38 h fermentation, pH 5.6, 430 W ultrasound at 58 °C, 42% NADES water content), the arctigenin yield reached 54.91 mg/g, 14.64-fold higher than in the raw herb (3.75 mg/g). NADES enhanced fungal growth, membrane permeability, and extracellular enzyme activity, facilitating bioconversion and extraction. This strategy effectively overcomes limitations of low arctigenin content and poor extraction efficiency, offering a promising approach for producing rare herbal compounds and insight into NADES-assisted whole-cell catalysis.
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