Evidence map›Paper›PMID 41186782›Full record

ArticleJournal of computer-aided molecular design2025

Design, synthesis, deep learning-guided prediction, and biological evaluation of novel pyridine-thiophene-based imine-benzalacetophenone hybrids as promising antimicrobial agent.

Krupa G Prajapati, Vikas A Desai, Mustafa Alhaji Isa, Riki P Tailor, Bhadresh R Sudani, Jignesh V Pandya

Abstract read
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In one paragraph

Article in Journal of computer-aided molecular design, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Krupa G PrajapatiDepartment of Chemistry, Sankalchand Patel University, Visnagar, India.
Vikas A DesaiB. K. M. Science College, Valsad, Gujarat, India.
Mustafa Alhaji IsaComputational Drug Discovery and Bioinformatics Research Group (CDDBRG), Center for Instructional Technology, University of Maiduguri, Maiduguri, Nigeria. mustafaisa@unimaid.edu.ng.
Riki P TailorSheth M. N. Science College, Patan, Gujarat, India.
Bhadresh R SudaniGovernment Engineering College, Valsad, Gujarat, India.
Jignesh V PandyaShri Sarvajanik PG Science College, Mehsana, Gujarat, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Antimicrobial resistance (AMR) remains a global health crisis, necessitating the development of novel therapeutics against multidrug-resistant pathogens. In this study, ten (10) hybrid imine-benzalacetophenone derivatives (7a-7j), incorporating pyridine and thiophene scaffolds, were synthesized and structurally characterized using FTIR,

Indexed as

Anti-Infective AgentsDrug DesignIminesPyridinesThiophenesDeep LearningMicrobial Sensitivity TestsMolecular Docking SimulationMycobacterium tuberculosisQuantitative Structure-Activity RelationshipAnti-Infective AgentsIminespyridinePyridinesThiophenesAntimicrobial resistanceDeep learning-based QSARImine-benzalacetophenone hybridsMolecular dockingMolecular dynamics simulation and pharmacokinetics

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.