Evidence map›Paper›PMID 41186755›Full record

ArticleFamilial cancer2025

Endoscopic papillectomy for ampullary adenomas in familial adenomatous polyposis.

C Wehling, Y Eckstein, A Stenzinger, N Ganion, T Bruckner, P Sauer, C C Zhang-Hagenlocher, M Kantowski, R Koschny

Abstract read
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In one paragraph

Article in Familial cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

C WehlingInterdisciplinary Endoscopy Center (IEZ)/Department of Gastroenterology, University Hospital Heidelberg, Im Neuenheimer Feld 410, 69120, Heidelberg, Germany.
Y EcksteinInterdisciplinary Endoscopy Center (IEZ)/Department of Gastroenterology, University Hospital Heidelberg, Im Neuenheimer Feld 410, 69120, Heidelberg, Germany.
A StenzingerInstitute of Pathology, University Hospital Heidelberg, Heidelberg, Germany.
N GanionDepartment of Anesthesiology, University Hospital Heidelberg, Heidelberg, Germany.
T BrucknerInstitute for Medical Biometry, University Hospital Heidelberg, Heidelberg, Germany.
P SauerInterdisciplinary Endoscopy Center (IEZ)/Department of Gastroenterology, University Hospital Heidelberg, Im Neuenheimer Feld 410, 69120, Heidelberg, Germany.
C C Zhang-HagenlocherInterdisciplinary Endoscopy Center (IEZ)/Department of Gastroenterology, University Hospital Heidelberg, Im Neuenheimer Feld 410, 69120, Heidelberg, Germany.
M KantowskiInterdisciplinary Endoscopy Center (IEZ)/Department of Gastroenterology, University Hospital Heidelberg, Im Neuenheimer Feld 410, 69120, Heidelberg, Germany.
R KoschnyInterdisciplinary Endoscopy Center (IEZ)/Department of Gastroenterology, University Hospital Heidelberg, Im Neuenheimer Feld 410, 69120, Heidelberg, Germany. Ronald.Koschny@med.uni-heidelberg.de.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objectives of the study were to determine the success, complication and recurrence rate of endoscopic papillectomies in familial adenomatous polyposis (FAP) patients. Ampullary adenoma is frequent in familial adenomatous polyposis (FAP) patients. Endoscopic papillectomy is technically demanding for laterally spreading ampullary adenomas and bleeding, perforation and pancreatitis represent typical complications. 40 FAP patients undergoing endoscopic papillectomy were retrospectively analyzed. Data on periprocedural complications, histopathology, resection techniques and success were collected. Endoscopic papillectomy was performed in 21 male and 19 female patients. Mean adenoma size was 14 mm (8-40 mm). Additional mucosal resection was performed in 45%. Immediate and delayed bleeding occurred in 33% (n = 13) and 13% (n = 5), respectively. Bleeding was associated with male sex and pancreatic endoprosthesis. Endoscopically manageable perforation occurred in 2 patients. Acute pancreatitis occurred in 25% (n = 10) and was significantly associated with female sex. Histopathology revealed papillitis in 5% (n = 2), adenoma with low-grade dysplasia in 73% (n = 29), high-grade dysplasia in 13% (n = 5), and adenocarcinoma in 5% (n = 2). Cumulative recurrence-free resection was achieved in 94% (n = 33/35) after a mean of 1.4 procedures at a median follow-up of 591 days (range 15-2605). Endoscopic papillectomy shows a high clinical success in FAP patients even with laterally spreading adenoma. Adenoma recurrence can be successfully treated with a limited number of reinterventions.

Indexed as

AdenomaAdenomatous Polyposis ColiAmpulla of VaterCommon Bile Duct NeoplasmsSphincterotomy, EndoscopicAdultAgedFemaleHumansMaleMiddle AgedNeoplasm Recurrence, LocalRetrospective StudiesTreatment OutcomeYoung AdultAmpullary cancerEndoscopic mucosal resectionEndoscopic papillectomyFamilial adenomatous polyposis coliPancreatitisPapilla of vater

Identifiers

PMID41186755
PMCPMC12586201

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