The impact of social phobia tendency on positive affect: the role of perceived control and its neural correlates.

Shaoyu Tu, Jingzhen He, Jiali Liu, Haichao Zhao, Ofir Turel, Qinghua He

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Article in Brain structure & function, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

6 authors.

Shaoyu TuFaculty of Psychology, MOE Key Laboratory of Cognition and Personality, Southwest University, Chongqing, 400715, China.

Jingzhen HeFaculty of Psychology, MOE Key Laboratory of Cognition and Personality, Southwest University, Chongqing, 400715, China.

Jiali LiuFaculty of Psychology, MOE Key Laboratory of Cognition and Personality, Southwest University, Chongqing, 400715, China.

Haichao ZhaoFaculty of Psychology, MOE Key Laboratory of Cognition and Personality, Southwest University, Chongqing, 400715, China.

Ofir TurelSchool of Computing and Information Systems, The University of Melbourne, Melbourne, 3010, Australia.

Qinghua HeFaculty of Psychology, MOE Key Laboratory of Cognition and Personality, Southwest University, Chongqing, 400715, China. heqinghua@swu.edu.cn.

Funding

Fundamental Research Funds for the Central Universities SWU2209235Innovation Research 2035 Pilot Plan of Southwest University SWUPilotPlan006National Natural Science Foundation of China 31972906Open Research Fund of the State Key Laboratory of Cognitive Neuroscience and Learning CNLYB2303)

6 · The paper itself

Abstract

Social phobia (SP) adversely affects individual as it often drives lower positive affect (PA) in social situations. This study aims to investigate the role of Lack of Control (LC) and its neural underpinnings in this process. We recruited 268 participants who completed measurements of SP tendency, LC, and PA at baseline (T1) and after two years (T2). All underwent a resting-state fMRI scan at T1. Findings revealed bidirectional associations among LC, SP tendency and PA, and the mediating effect of LC. Specifically, the LC at T1 was associated with SP tendency (β = 0.164) and PA (β = -0.191) at T2, while SP tendency (β = 0.103) and PA (β = -0.175) at T1 were associated with LC at T2. Additionally, Functional connectivity (FC) analyses and brain-behavior models further demonstrated that: (1) SP tendency at T1 was associated with LC at T2 through the FC networks involving the bilateral angular gyrus and left middle occipital gyrus (point estimate = -0.045, 95% CI [-0.070, -0.019]), and (2) LC at T2 was associated with PA at T2 via the FC networks of the left lingual gyrus, right cuneus and fusiform gyrus (point estimate = 0.040, 95% CI [0.007, 0.058]). This elucidates the cognitive and neural correlates through which SP tendency negatively affects PA, emphasizing the crucial role of LC in this relationship. Unraveling this mechanism offers a potential path for clinical interventions aimed at improving the mental health of individuals high in SP tendency.

Indexed as

AffectBrainPhobia, SocialAdultBrain MappingFemaleHumansMagnetic Resonance ImagingMaleNeural PathwaysYoung AdultLosing controlPositive affectResting-state fMRISocial phobia

Identifiers

PMID41186751

DOI10.1016/j.ijchp.2022.100345

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.