ArticleAbdominal radiology (New York)2026
Intra-individual comparison of abbreviated gadoxetic acid-enhanced MRI and contrast-enhanced CT for postoperative surveillance of colorectal liver metastases: a multicenter prospective study.
Article in Abdominal radiology (New York), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
purposeTo intra-individually compare the diagnostic performance of hepatobiliary phase (HBP)-abbreviated MRI (AMRI) and contrast-enhanced CT (CE-CT) in postoperative surveillance of colorectal liver metastases (CRLMs).
methodsThis multicenter prospective study enrolled 462 patients with colorectal cancer who underwent paired CE-CT and HBP-AMRI every six months over a 24-month surveillance period. The HBP-AMRI protocol comprised T2-weighted imaging, diffusion-weighted imaging, and HBP at 10 min post-injection, with total acquisition optimized to 5 min. Lesion detection rates for all and subcentimeter lesions, and patient-level sensitivity, specificity, and accuracy were compared between CE-CT and HBP-AMRI by McNemar χ
resultsHBP-AMRI demonstrated significantly higher detection rates than CE-CT across all surveillance rounds for all and subcentimeter lesions (all P < 0.05). The pooled 24-month data demonstrated HBP-AMRI significantly outperformed CE-CT in specificity (overall: 94.35% vs. 86.92%; P < 0.001), and accuracy (overall: 94.04% vs. 86.23%; P < 0.001). A consistent trend was observed across each individual surveillance round. The pooled 24-month analysis revealed HBP-AMRI had significantly higher sensitivity than CE-CT (overall: 90.35% vs. 78.07%; P = 0.023). HBP-AMRI maintained a superior negative predictive value (NPV) compared with CE-CT (overall: 99.14% vs. 97.91%), and higher positive predictive value (PPV) compared with CE-CT (overall: 57.54% vs. 33.59%) across all surveillance rounds.
conclusionHBP-AMRI with a 5-minute streamlined workflow substantially outperforms CE-CT in lesion detection rate and patient-level diagnostic performance of CRLMs. HBP-AMRI can provide an efficient and safe alternative modality with longitudinal reliability for postoperative surveillance of CRLM in colorectal cancer patients.
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