Evidence map›Paper›PMID 41186702›Full record

ArticleClinical research in cardiology : official journal of the German Cardiac Society2026

Left ventriculo-arterial coupling in a contemporary cohort of patients with wild-type transthyretin cardiac amyloidosis treated with tafamidis.

Giuseppe Damiano Sanna, Valeria Anna Di Simone, Paolo Milani, Alessandro Fogliani, Roberta Mussinelli, Gianluigi Guida, Andrea Attanasio, Laura Obici, Marco Basset, Martina Nanci and 7 more

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Article in Clinical research in cardiology : official journal of the German Cardiac Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Giuseppe Damiano SannaDepartment of Molecular Medicine, University of Pavia, Pavia, Italy.
Valeria Anna Di SimoneDepartment of Molecular Medicine, University of Pavia, Pavia, Italy.
Paolo MilaniDepartment of Molecular Medicine, University of Pavia, Pavia, Italy.
Alessandro FoglianiDepartment of Internal Medicine, University of Pavia, Foundation IRCCS San Matteo, Amyloid Research and Treatment Center, Pavia, Italy.
Roberta MussinelliDepartment of Internal Medicine, University of Pavia, Foundation IRCCS San Matteo, Amyloid Research and Treatment Center, Pavia, Italy.
Gianluigi GuidaClinical Cardiology, IRCCS Policlinico San Donato, Milan, Italy.
Andrea AttanasioClinical Cardiology, IRCCS Policlinico San Donato, Milan, Italy.
Laura ObiciDepartment of Internal Medicine, University of Pavia, Foundation IRCCS San Matteo, Amyloid Research and Treatment Center, Pavia, Italy.
Marco BassetDepartment of Internal Medicine, University of Pavia, Foundation IRCCS San Matteo, Amyloid Research and Treatment Center, Pavia, Italy.
Martina NanciDepartment of Internal Medicine, University of Pavia, Foundation IRCCS San Matteo, Amyloid Research and Treatment Center, Pavia, Italy.
Andrea FoliDepartment of Internal Medicine, University of Pavia, Foundation IRCCS San Matteo, Amyloid Research and Treatment Center, Pavia, Italy.
Gavino CasuClinical and Interventional Cardiology, Sassari University Hospital, Sassari, Italy.
Leonardo De LucaDivision of Cardiology, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
Mario NuvoloneDepartment of Molecular Medicine, University of Pavia, Pavia, Italy.
Giampaolo MerliniDepartment of Molecular Medicine, University of Pavia, Pavia, Italy.
Stefano PerliniUniversity of Pavia, Department of Internal Medicine, Viale Golgi, 19, Pavia, 27100, Italy. stefano.perlini@unipv.it.ORCID http://orcid.org/0000-0002-0320-8574
Giovanni PalladiniDepartment of Molecular Medicine, University of Pavia, Pavia, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundWild-type transthyretin amyloid cardiomyopathy (ATTRwt-CM) is characterized by a labile equilibrium between preload and afterload. A tailored approach to supporting medical therapy based on noninvasive parameters able to describe the properties of both heart and systemic vasculature, and their interactions is required. However, data on ventriculo-arterial coupling (VAC) in ATTRwt-CM is lacking.

objectivesTo describe ventriculo-arterial coupling (VAC) and its clinical correlates in a contemporary cohort of patients with ATTRwt-CM.

methodsThe VAC, defined as the ratio between arterial (E

resultsThe study included 114 patients treated with the transthyretin stabilizer tafamidis from a national referral centre (median age 79 years; 89% males). Median values were 1.48 (1.22-1.84) mmHg/ml for E

conclusionIn ATTRwt-CM patients, arterial and ventricular elastances and VAC are independent predictors of worse clinical status and more advanced disease stage.

Indexed as

Amyloid Neuropathies, FamilialBenzoxazolesCardiomyopathiesHeart VentriclesVentricular Function, LeftAgedAged, 80 and overFemaleHumansMaleMiddle AgedStroke VolumeTreatment OutcomeBenzoxazolestafamidisArterial elastanceEchocardiographyVentricular elastanceVentriculo-arterial couplingWild-type transthyretin cardiac amyloidosis

Identifiers

PMID41186702
PMCPMC13083476

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