ArticleAnalytical and bioanalytical chemistry2025
Exploring ammonium salt doping to enhance ion abundance for quantitative mass spectrometry imaging.
Article in Analytical and bioanalytical chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Article
- Signal enhancement of lipids and glycans using ammonium fluoride for IR-MALDESI mass spectrometry imaging.Analytical and bioanalytical chemistry · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Increasing ion abundance in mass spectrometry is essential for enhancing detection, quantification, and understanding of biomolecules involved in key cellular processes. Infrared matrix-assisted laser desorption electrospray ionization (IR-MALDESI), MALDI, and nano-DESI have shown improved ion abundance when integrating specific concentrations of ammonium fluoride into the sample preparation and/or ionization steps. Herein, the importance of electronegativity and atomic size for the proposed mechanism of increased ion abundance is evaluated by testing a variety of ammonium halide salts. Ammonium fluoride was confirmed to result in the largest increase in ion abundance and was subsequently used to perform quantitative mass spectrometry imaging (qMSI) of glutathione (GSH) in healthy mouse liver tissue. Using ~70 µM NH
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.