Evidence map›Paper›PMID 41186653›Full record

ArticleHigh blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension2026

Mediating Role of Insulin Resistance in the Association Between Body Composition and Hypertension.

Qingfang Deng, Hao Kang, Yu Cao, Rui Tian, Dengke Chen, Hui Yu, Jioajiao Zhu, Yanling He, Jie Zhang, Xing Liu and 2 more

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Article in High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

12 authors.

Qingfang DengSchool of Public Health, Anhui Medical University, No 81 Meishan Road, Hefei, 230032, Anhui, China.
Hao KangSchool of Public Health, Anhui Medical University, No 81 Meishan Road, Hefei, 230032, Anhui, China.
Yu CaoSchool of Public Health, Anhui Medical University, No 81 Meishan Road, Hefei, 230032, Anhui, China.
Rui TianSchool of Public Health, Anhui Medical University, No 81 Meishan Road, Hefei, 230032, Anhui, China.
Dengke ChenSchool of Public Health, Anhui Medical University, No 81 Meishan Road, Hefei, 230032, Anhui, China.
Hui YuSchool of Public Health, Anhui Medical University, No 81 Meishan Road, Hefei, 230032, Anhui, China.
Jioajiao ZhuHongguang Street Community Health Service Center, Hefei, China.
Yanling HeHongguang Street Community Health Service Center, Hefei, China.
Jie ZhangHongguang Street Community Health Service Center, Hefei, China.
Xing LiuHongguang Street Community Health Service Center, Hefei, China.
Jie ShengSchool of Public Health, Anhui Medical University, No 81 Meishan Road, Hefei, 230032, Anhui, China.
Sufang WangSchool of Public Health, Anhui Medical University, No 81 Meishan Road, Hefei, 230032, Anhui, China. wangsufangdev@ahmu.edu.cn.ORCID http://orcid.org/0000-0002-2503-961X

Funding

Innovative Research Group Project of the National Natural Science Foundation of China 81102125
6 · The paper itself

Abstract

introductionHypertension, a major cardiovascular risk, is affected by body composition and metabolism.

aimWe assessed the associations of body composition with hypertension and the mediating role of insulin resistance (IR).

methodsIn Hefei Hongsifang Company, 743 employees aged 40-60 were recruited consecutively. Logistic regression was used to assess the association between body composition and hypertension risk. Mediation analysis was conducted to explore the mediating role of IR between body composition and hypertension risk.

resultsIndividuals with higher body fat percentage (BF%) (OR = 2.44, 95% CI 1.64-3.65, P < 0.001) and Visceral adiposity index (VAI) (OR = 2.22, 95% CI 1.39-3.55, P < 0.001) had significantly higher odds of hypertension. Conversely, higher levels of skeletal muscle mass percentage (SMM%) (OR = 0.35, 95% CI 0.21-0.56, P < 0.001), total body water percentage (TBW%) (OR = 0.36, 95% CI 0.23-0.59, P < 0.001), and bone mineral content percentage (BMC%) (OR = 0.34, 95% CI 0.21-0.54, P < 0.001) were all linked to lower odds of hypertension. IR significantly mediated the associations between body composition and hypertension risk. The mediation proportions were as follows: 29.4% for BF%, 61.5% for VAI, 33.7% for SMM%, 34.9% for TBW%, and 31.4% for BMC%.

conclusionOur study demonstrated that, in middle-aged individuals, lower BF% and VAI, as well as higher SMM%, TBW%, and BMC%, were independently associated with a reduced risk of hypertension. IR partially mediated the associations between body composition and hypertension.

Indexed as

AdiposityBlood PressureBody CompositionHypertensionInsulin ResistanceAdultCross-Sectional StudiesFemaleHumansIntra-Abdominal FatMaleMiddle AgedRisk AssessmentRisk FactorsBody compositionHypertensionIR

Identifiers

PMID41186653

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