Evidence map›Paper›PMID 41186627›Full record

ArticleDiscover oncology2025

Systems biology-driven identification of biomarkers and significant pathways in radiation-induced hormone-sensitive cancers.

Suvitha Anbarasu, Sathyanarayan Balaji, Sudha Ramaiah, Anand Anbarasu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Discover oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Suvitha AnbarasuDepartment of Biotechnology, School of Bioscience and Technology (SBST), Vellore Institute of Technology (VIT), Vellore, Tamil Nadu, 632014, India.ORCID http://orcid.org/0000-0001-5204-6121
Sathyanarayan BalajiDepartment of Biotechnology, School of Bioscience and Technology (SBST), Vellore Institute of Technology (VIT), Vellore, Tamil Nadu, 632014, India.ORCID http://orcid.org/0009-0009-9746-2204
Sudha RamaiahMedical and Biological Computing Laboratory, School of Bioscience and Technology (SBST), Vellore Institute of Technology (VIT), Vellore, Tamil Nadu, 632014, India.ORCID http://orcid.org/0000-0002-4800-329X
Anand AnbarasuDepartment of Biotechnology, School of Bioscience and Technology (SBST), Vellore Institute of Technology (VIT), Vellore, Tamil Nadu, 632014, India. aanand@vit.ac.in.ORCID http://orcid.org/0000-0003-2216-7488

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Radiation-induced damage to nucleic acid and other important cellular constituents could likely cause cancer. The present study has analyzed mutated genes with dysregulated expression signatures due to radiation. We have predicted biomarkers specific to hormone-sensitive cancers (HSCs) namely breast cancer (BC), prostate cancer (PC), ovarian cancer (OC), and endometrial cancer (EC). The study has also attempted to prospect the pathways associated with HSCs and radiation exposure through network analysis and functional enrichment analysis. An overlap of important cell cycle pathways, DNA binding, and transcription activity pathways were found in comparison with HSCs and the radiation hallmark pathways. Hub genes TNF, STAT3, CTNNB1, and MYC in BC; IL1B, CTNNB1, ESR1, and SRC in PC; CTNNB1, BRCA1, JUN, and KRAS in OC; PIK3CA, PTEN, and ESR1 in EC were found as hypoxic signatures due to radiation. Further, the expression survival analysis found MYC and STAT3 in BC, CTNNB1 in PC, JUN, and BRCA1 in OC, and ESR1 in EC were significantly dysregulated and further mutational profiling validated MYC with 18%, STAT3 with 2.6%, and all other genes with 4% mutation. Thus, these genes are proposed as radiation-sensitive diagnostic biomarkers in HSCs.

Indexed as

Differential expressionHypoxiaIonizing radiationNucleic acid damageSurvival

Identifiers

PMID41186627
PMCPMC12586841

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.