ReviewCellular and molecular neurobiology2025
Chronic Neuroplasticity Changes Following Neurotropic Viral Infection: Mechanisms and Implications.
Review in Cellular and molecular neurobiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed.
- Establishment of an in vitro human blood-brain barrier model for antiviral screening against neurotropic viruses.Fluids and barriers of the CNS · 2026Article
- Beyond the neuron: the role of glial cells in viral neuropathogenesis.Journal of virology · 2026Review
- Multiscale systems modelling of communication networks in brain metastasis.Experimental & molecular medicine · 2026Review
- Convergence of neuroinflammation across major neurotropic viral exposomes in AD and ADRD.Journal of neuroinflammation · 2026Review
- The prefrontal cortex as a target of HIV-1 neurotoxicity: molecular mechanisms of viral protein-mediated neurodegeneration and executive dysfunction.Frontiers in cellular neuroscience · 2026Review
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The nervous system exhibits remarkable adaptability through neuroplasticity, which allows for structural and functional changes in response to intrinsic and extrinsic stimuli. This dynamic process underpins synaptic formation, elimination, learning, memory, and brain recovery after neurological insults. However, neuroplasticity can be compromised by neurotropic viral infections, which present significant challenges to the central nervous system (CNS). Viruses infiltrate the CNS through various mechanisms, including peripheral nerves, disruption of the blood-brain barrier (BBB), and evasion of the immune system, leading to acute or chronic neuronal pathologies. Moreover, these infections may trigger encephalitis, neuroinflammation, and synaptic dysfunction, thereby impairing neural circuits and compromising brain function. Persistent viral infection and chronic responses further exacerbate neuronal damage through oxidative stress, excitotoxicity, and disruption of neural progenitor cells. Collectively, these effects hinder neuroplasticity, resulting in cognitive deficits, behavioral changes, and long-lasting structural alterations. Understanding the mechanisms by which neurotropic viruses impair neuroplasticity is crucial for developing targeted therapeutic interventions. Strategies aimed at addressing viral persistence, mitigating inflammation, and promoting synaptic repair are critical to preserving brain health and functionality. This review provides a comprehensive overview of virus-induced neuronal pathologies and their effects on neuroplasticity, highlighting the importance of innovative treatments to enhance CNS resilience and recovery in affected individuals.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.