Evidence map›Paper›PMID 41186598›Full record

ArticleACS infectious diseases2025

Extending Thioflavin T Fluorescence Probe to 2-Ethenyl-benzothiazole Derivatives: Drug-like Quadruplex Ligands with Potent Antitrypanosomatid Activity.

Raquel C R Gonçalves, Pablo Peñalver, Nina M Allen, Efres Belmonte-Reche, Belén García-Pérez, Susana P G Costa, Y Jennifer Jiang, José María Pérez-Victoria, M Carmen Galan, M Manuela M Raposo and 1 more

Abstract read
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In one paragraph

Article in ACS infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Raquel C R GonçalvesCentre of Chemistry, University of Minho, Campus of Gualtar, 4710-057 Braga, Portugal.
Pablo PeñalverDepartamento de Biología y Farmacología Molecular, Instituto de Parasitología y Biomedicina López Neyra, CSIC, PTS Granada, Avenida del Conocimiento, 17, Armilla, 18016 Granada, Spain.
Nina M AllenSchool of Chemistry, University of Bristol, Bristol BS8 1TS, U.K.
Efres Belmonte-RecheCentre for Genomics and Oncological Research, Pfizer/University of Granada/Andalusian Regional Government, GENYO, PTS Granada, Av. de la Ilustración, 114, 18016 Granada, Spain.
Belén García-PérezDepartamento de Biología y Farmacología Molecular, Instituto de Parasitología y Biomedicina López Neyra, CSIC, PTS Granada, Avenida del Conocimiento, 17, Armilla, 18016 Granada, Spain.
Susana P G CostaCentre of Chemistry, University of Minho, Campus of Gualtar, 4710-057 Braga, Portugal.
Y Jennifer JiangSchool of Chemistry, University of Bristol, Bristol BS8 1TS, U.K.
José María Pérez-VictoriaDepartamento de Biología y Farmacología Molecular, Instituto de Parasitología y Biomedicina López Neyra, CSIC, PTS Granada, Avenida del Conocimiento, 17, Armilla, 18016 Granada, Spain.
M Carmen GalanSchool of Chemistry, University of Bristol, Bristol BS8 1TS, U.K.
M Manuela M RaposoCentre of Chemistry, University of Minho, Campus of Gualtar, 4710-057 Braga, Portugal.ORCID 0000-0002-7996-1626
Juan Carlos MoralesDepartamento de Biología y Farmacología Molecular, Instituto de Parasitología y Biomedicina López Neyra, CSIC, PTS Granada, Avenida del Conocimiento, 17, Armilla, 18016 Granada, Spain.ORCID 0000-0003-2400-405X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Thioflavin T (ThT) is a well-established fluorescence probe with selectivity for G-quadruplex (G4) structures. Over the past few years, G4 ligands have emerged as promising candidates for the development of antiparasitic agents. Building on this concept, we explored extending ThT's benzothiazole scaffold by introducing various 2-ethenyl aromatic and heteroaromatic moieties, aiming to enhance G4 binding affinity and potential therapeutic effect. A series of benzothiazolium derivatives were synthesized and evaluated for their antiproliferative and antiparasitic activity. Several 2-ethenyl benzothiazole derivatives showed submicromolar activity against

Indexed as

Antiprotozoal AgentsBenzothiazolesFluorescent DyesG-QuadruplexesTrypanosoma brucei bruceiCell LineHumansLeishmaniaLeishmania majorLigandsAntiprotozoal AgentsbenzothiazoleBenzothiazolesFluorescent DyesLigandsthioflavin TAfrican trypanosomiasisantiparasitic agentsbenzothiazolium derivativesG-quadruplex ligandsleishmaniasis

Identifiers

PMID41186598
PMCPMC12643529

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.